Efficient Methods for Selecting Sirna Sequences by Using the Average Silencing Probability and a Hidden Markov Model

Short interfering RNA (siRNA) has been widely used for studying gene functions in mammalian cells but varies markedly in its gene silencing efficacy. Although many design rules/guidelines for effective siRNAs based on various criteria have been reported recently, there are only a few consistencies a...

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Veröffentlicht in:	Journal of computer science and systems biology 2014-01, Vol.7 (1), p.45-45
1. Verfasser:	Takasaki, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Consistency Design engineering Gene sequencing Genes Guidelines Mammals Mathematical models
Online-Zugang:	Volltext
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