Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe)
Endocrine disruptors (EDs) interfere with the development and functioning of the endocrine system, causing reproductive disturbance in aquatic wildlife. The aim of the present work was to determine the presence of EDs in sediments and to investigate possible exposure and effects of EDs in the estuar...
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| creator | Puy-Azurmendi, Eunate Ortiz-Zarragoitia, Maren Villagrasa, Marta Kuster, Marina Aragón, Pilar Atienza, Julia Puchades, Rosa Maquieira, Angel Domínguez, Carmen López de Alda, Miren Fernandes, Denise Porte, Cinta Bayona, Josep M. Barceló, Damià Cajaraville, Miren P. |
| description | Endocrine disruptors (EDs) interfere with the development and functioning of the endocrine system, causing reproductive disturbance in aquatic wildlife. The aim of the present work was to determine the presence of EDs in sediments and to investigate possible exposure and effects of EDs in the estuary of the Urdaibai Biosphere Reserve (Gernika) in comparison with the Arriluze marina. For this, gonad histology, plasma vitellogenin (VTG) protein levels and mRNA levels of vitellogenin (vtg), cyp19 aromatases, estrogen receptor (er) and retinoid X receptor (rxr) were studied in Chelon labrosus. The presence of alkylphenols (APs) in fish bile was also assessed. In sediments, estrogenic hormones were below the detection limit and levels of bisphenol A were very low. In Gernika organotin compounds were low but in Arriluze levels of up to 12μg/g were found. Moderate levels of APs and phthalate levels of up to 8μg/g were found in sediments. In fish, a high prevalence up to 33% of intersex gonads was found in Gernika, whereas only one intersex was found in Arriluze. Accordingly, mullets from Gernika showed higher concentrations of APs in bile. VTG protein levels were detected not only in females but also in some undifferentiated, male and intersex fish. mRNA of vtg was detected in one male from Gernika. mRNA of er and rxr showed significant differences between seasons. In conclusion, the present study demonstrated that C. labrosus from the Urdaibai estuary were exposed to EDs and showed clear signs of endocrine disruption.
► High prevalence of intersex gonads was found in the Urdaibai Biosphere Reserve. ► High levels of alkylphenols were measured in fish bile. ► VTG protein was detected in the plasma of undifferentiated, male and intersex fish. ► Levels of phthalate and organotins measured in sediments are of great concern. ► This study provided evidence of EDs presence in the Urdaibai Biosphere Reserve. |
| doi_str_mv | 10.1016/j.scitotenv.2012.10.078 |
| format | Article |
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► High prevalence of intersex gonads was found in the Urdaibai Biosphere Reserve. ► High levels of alkylphenols were measured in fish bile. ► VTG protein was detected in the plasma of undifferentiated, male and intersex fish. ► Levels of phthalate and organotins measured in sediments are of great concern. ► This study provided evidence of EDs presence in the Urdaibai Biosphere Reserve.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2012.10.078</identifier><identifier>PMID: 23195039</identifier><identifier>CODEN: STENDL</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Base Sequence ; Biological and medical sciences ; Biosphere ; Brackish ; Chelon labrosus ; Disorders of Sex Development ; Disruption ; DNA Primers ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Endocrine Disruptors - toxicity ; Endocrine disruptors in sediments and fish bile ; Enzyme-Linked Immunosorbent Assay ; Estuaries ; Europe ; Expression of aromatase and nuclear receptors ; Female ; Fish ; Fundamental and applied biological sciences. Psychology ; Gas Chromatography-Mass Spectrometry ; Geologic Sediments - chemistry ; Gonads ; Intersex gonad ; Male ; Males ; Receptors ; Reserves ; RNA, Messenger - genetics ; Sediments ; Smegmamorpha ; Thicklip grey mullet Chelon labrosus ; Transcription, Genetic ; Urdaibai Biosphere Reserve ; Vitellogenin ; Vitellogenins - blood ; Vitellogenins - genetics ; Water Pollutants, Chemical - toxicity</subject><ispartof>The Science of the total environment, 2013-01, Vol.443, p.233-244</ispartof><rights>2012 Elsevier B.V.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-eca62501d6eb28c404d1048fbfc314e37d0ce3f513773c085f6de40a08b6faab3</citedby><cites>FETCH-LOGICAL-c500t-eca62501d6eb28c404d1048fbfc314e37d0ce3f513773c085f6de40a08b6faab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2012.10.078$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27129990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23195039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puy-Azurmendi, Eunate</creatorcontrib><creatorcontrib>Ortiz-Zarragoitia, Maren</creatorcontrib><creatorcontrib>Villagrasa, Marta</creatorcontrib><creatorcontrib>Kuster, Marina</creatorcontrib><creatorcontrib>Aragón, Pilar</creatorcontrib><creatorcontrib>Atienza, Julia</creatorcontrib><creatorcontrib>Puchades, Rosa</creatorcontrib><creatorcontrib>Maquieira, Angel</creatorcontrib><creatorcontrib>Domínguez, Carmen</creatorcontrib><creatorcontrib>López de Alda, Miren</creatorcontrib><creatorcontrib>Fernandes, Denise</creatorcontrib><creatorcontrib>Porte, Cinta</creatorcontrib><creatorcontrib>Bayona, Josep M.</creatorcontrib><creatorcontrib>Barceló, Damià</creatorcontrib><creatorcontrib>Cajaraville, Miren P.</creatorcontrib><title>Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe)</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Endocrine disruptors (EDs) interfere with the development and functioning of the endocrine system, causing reproductive disturbance in aquatic wildlife. The aim of the present work was to determine the presence of EDs in sediments and to investigate possible exposure and effects of EDs in the estuary of the Urdaibai Biosphere Reserve (Gernika) in comparison with the Arriluze marina. For this, gonad histology, plasma vitellogenin (VTG) protein levels and mRNA levels of vitellogenin (vtg), cyp19 aromatases, estrogen receptor (er) and retinoid X receptor (rxr) were studied in Chelon labrosus. The presence of alkylphenols (APs) in fish bile was also assessed. In sediments, estrogenic hormones were below the detection limit and levels of bisphenol A were very low. In Gernika organotin compounds were low but in Arriluze levels of up to 12μg/g were found. Moderate levels of APs and phthalate levels of up to 8μg/g were found in sediments. In fish, a high prevalence up to 33% of intersex gonads was found in Gernika, whereas only one intersex was found in Arriluze. Accordingly, mullets from Gernika showed higher concentrations of APs in bile. VTG protein levels were detected not only in females but also in some undifferentiated, male and intersex fish. mRNA of vtg was detected in one male from Gernika. mRNA of er and rxr showed significant differences between seasons. In conclusion, the present study demonstrated that C. labrosus from the Urdaibai estuary were exposed to EDs and showed clear signs of endocrine disruption.
► High prevalence of intersex gonads was found in the Urdaibai Biosphere Reserve. ► High levels of alkylphenols were measured in fish bile. ► VTG protein was detected in the plasma of undifferentiated, male and intersex fish. ► Levels of phthalate and organotins measured in sediments are of great concern. ► This study provided evidence of EDs presence in the Urdaibai Biosphere Reserve.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biosphere</subject><subject>Brackish</subject><subject>Chelon labrosus</subject><subject>Disorders of Sex Development</subject><subject>Disruption</subject><subject>DNA Primers</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Endocrine disruptors in sediments and fish bile</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Estuaries</subject><subject>Europe</subject><subject>Expression of aromatase and nuclear receptors</subject><subject>Female</subject><subject>Fish</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Geologic Sediments - chemistry</subject><subject>Gonads</subject><subject>Intersex gonad</subject><subject>Male</subject><subject>Males</subject><subject>Receptors</subject><subject>Reserves</subject><subject>RNA, Messenger - genetics</subject><subject>Sediments</subject><subject>Smegmamorpha</subject><subject>Thicklip grey mullet Chelon labrosus</subject><subject>Transcription, Genetic</subject><subject>Urdaibai Biosphere Reserve</subject><subject>Vitellogenin</subject><subject>Vitellogenins - blood</subject><subject>Vitellogenins - genetics</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-O0zAQxi0EYsvCK4AvSF2JlLGdxMlxtyp_pJWQgD1Hjj2mLmkc7KSoT8Br46hlOe76YsnzG8838w0hbxisGLDy_W4VtRv9iP1hxYHx9LoCWT0hC1bJOmPAy6dkAZBXWV3W8oK8iHEH6ciKPScXXLC6AFEvyJ9Nb7wOrkdqXAzTMDrfU9fTcev0z84N9EfAI91PXYcjXa632KV4p9rg4xSvqA1-n1ikd8Eo1ypHb5yPwxYD0q8YMRyQLm_UkXqbIlGr4zv6zU_j9jfGEUNPN1PwA169JM-s6iK-Ot-X5O7D5vv6U3b75ePn9fVtpguAMUOtSl4AMyW2vNI55IalJm1rtWA5CmlAo7AFE1IKDVVhS4M5KKja0irVikuyPP07BP9rShqafVKFXad69FNsmJQgCg558TBa5jKNHvgjUF4VUOeyhMegvBJFKWZUnlCdhh0D2mYIbq_CsWHQzGvQ7Jr7NWjmNZgDyeKU-fpcZGr3aO7z_vmegLdnQCVPOhtUr138z0nG67qeJVyfOEyeHByGuSD2Go0LqMfGePegmL9tbNVl</recordid><startdate>20130115</startdate><enddate>20130115</enddate><creator>Puy-Azurmendi, Eunate</creator><creator>Ortiz-Zarragoitia, Maren</creator><creator>Villagrasa, Marta</creator><creator>Kuster, Marina</creator><creator>Aragón, Pilar</creator><creator>Atienza, Julia</creator><creator>Puchades, Rosa</creator><creator>Maquieira, Angel</creator><creator>Domínguez, Carmen</creator><creator>López de Alda, Miren</creator><creator>Fernandes, Denise</creator><creator>Porte, Cinta</creator><creator>Bayona, Josep M.</creator><creator>Barceló, Damià</creator><creator>Cajaraville, Miren P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>7TN</scope><scope>7TV</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope><scope>7SU</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20130115</creationdate><title>Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe)</title><author>Puy-Azurmendi, Eunate ; Ortiz-Zarragoitia, Maren ; Villagrasa, Marta ; Kuster, Marina ; Aragón, Pilar ; Atienza, Julia ; Puchades, Rosa ; Maquieira, Angel ; Domínguez, Carmen ; López de Alda, Miren ; Fernandes, Denise ; Porte, Cinta ; Bayona, Josep M. ; Barceló, Damià ; Cajaraville, Miren P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-eca62501d6eb28c404d1048fbfc314e37d0ce3f513773c085f6de40a08b6faab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biosphere</topic><topic>Brackish</topic><topic>Chelon labrosus</topic><topic>Disorders of Sex Development</topic><topic>Disruption</topic><topic>DNA Primers</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Endocrine disruptors in sediments and fish bile</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Estuaries</topic><topic>Europe</topic><topic>Expression of aromatase and nuclear receptors</topic><topic>Female</topic><topic>Fish</topic><topic>Fundamental and applied biological sciences. 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The aim of the present work was to determine the presence of EDs in sediments and to investigate possible exposure and effects of EDs in the estuary of the Urdaibai Biosphere Reserve (Gernika) in comparison with the Arriluze marina. For this, gonad histology, plasma vitellogenin (VTG) protein levels and mRNA levels of vitellogenin (vtg), cyp19 aromatases, estrogen receptor (er) and retinoid X receptor (rxr) were studied in Chelon labrosus. The presence of alkylphenols (APs) in fish bile was also assessed. In sediments, estrogenic hormones were below the detection limit and levels of bisphenol A were very low. In Gernika organotin compounds were low but in Arriluze levels of up to 12μg/g were found. Moderate levels of APs and phthalate levels of up to 8μg/g were found in sediments. In fish, a high prevalence up to 33% of intersex gonads was found in Gernika, whereas only one intersex was found in Arriluze. Accordingly, mullets from Gernika showed higher concentrations of APs in bile. VTG protein levels were detected not only in females but also in some undifferentiated, male and intersex fish. mRNA of vtg was detected in one male from Gernika. mRNA of er and rxr showed significant differences between seasons. In conclusion, the present study demonstrated that C. labrosus from the Urdaibai estuary were exposed to EDs and showed clear signs of endocrine disruption.
► High prevalence of intersex gonads was found in the Urdaibai Biosphere Reserve. ► High levels of alkylphenols were measured in fish bile. ► VTG protein was detected in the plasma of undifferentiated, male and intersex fish. ► Levels of phthalate and organotins measured in sediments are of great concern. ► This study provided evidence of EDs presence in the Urdaibai Biosphere Reserve.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>23195039</pmid><doi>10.1016/j.scitotenv.2012.10.078</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0048-9697 |
| ispartof | The Science of the total environment, 2013-01, Vol.443, p.233-244 |
| issn | 0048-9697 1879-1026 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1770352045 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Base Sequence Biological and medical sciences Biosphere Brackish Chelon labrosus Disorders of Sex Development Disruption DNA Primers Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Endocrine Disruptors - toxicity Endocrine disruptors in sediments and fish bile Enzyme-Linked Immunosorbent Assay Estuaries Europe Expression of aromatase and nuclear receptors Female Fish Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Geologic Sediments - chemistry Gonads Intersex gonad Male Males Receptors Reserves RNA, Messenger - genetics Sediments Smegmamorpha Thicklip grey mullet Chelon labrosus Transcription, Genetic Urdaibai Biosphere Reserve Vitellogenin Vitellogenins - blood Vitellogenins - genetics Water Pollutants, Chemical - toxicity |
| title | Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T20%3A40%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endocrine%20disruption%20in%20thicklip%20grey%20mullet%20(Chelon%20labrosus)%20from%20the%20Urdaibai%20Biosphere%20Reserve%20(Bay%20of%20Biscay,%20Southwestern%20Europe)&rft.jtitle=The%20Science%20of%20the%20total%20environment&rft.au=Puy-Azurmendi,%20Eunate&rft.date=2013-01-15&rft.volume=443&rft.spage=233&rft.epage=244&rft.pages=233-244&rft.issn=0048-9697&rft.eissn=1879-1026&rft.coden=STENDL&rft_id=info:doi/10.1016/j.scitotenv.2012.10.078&rft_dat=%3Cproquest_cross%3E1770352045%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1282835630&rft_id=info:pmid/23195039&rft_els_id=S0048969712013691&rfr_iscdi=true |