The effects of swainsonine on the activity and expression of α-mannosidase in BRL-3A cells

Swainsonine (SW) is the principal toxic ingredient of locoweeds, which can cause intensive vacuolar degeneration because of α-mannosidase inhibition after animal ingestion. While SW can lead to obvious liver damage in vivo, the mechanism of hepatotoxic damage caused by SW is not clear. Therefore, BR...

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Veröffentlicht in:	Toxicon (Oxford) 2015-06, Vol.99, p.44-50
Hauptverfasser:	Lu, Hao, Ma, Feng, Wang, Huan, Geng, Peng-shuai, Wang, Shan-shan, Wang, Jian-guo, Wu, Chen-chen, Zhao, Bao-yu
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Mannosidase - antagonists & inhibitors alpha-Mannosidase - genetics alpha-Mannosidase - metabolism Animals Biocompatibility Biomedical materials BRL-3A cells Cell Line Cell Survival - drug effects China Damage Enzyme Repression - drug effects Gene expression Golgi Apparatus - drug effects Golgi Apparatus - enzymology Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - metabolism In vivo testing In vivo tests Inhibition Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Kinetics Locoweed Lysosomes - drug effects Lysosomes - enzymology MAN2A1 MAN2B1 Oxytropis - chemistry Proteins Rats RNA, Messenger - metabolism Swainsonine Swainsonine - toxicity Toxins, Biological - toxicity
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