Voltammetric determination of antibacterial drug gemifloxacin in solubilized systems at multi-walled carbon nanotubes modified glassy carbon electrode
[Display omitted] ▶ Squarewave method is linear over range 2.47–15.5μg/mL with LOD of 0.90ng/mL. ▶ Proposed method is more sensitive comparison to reported analytical methods. ▶ Use of solubilized system increases sensitivity for determination of gemifloxacin. A sensitive electroanalytical method fo...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2011-04, Vol.83 (2), p.340-346 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Jain, Rajeev Rather, Jahangir Ahmad |
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▶ Squarewave method is linear over range 2.47–15.5μg/mL with LOD of 0.90ng/mL. ▶ Proposed method is more sensitive comparison to reported analytical methods. ▶ Use of solubilized system increases sensitivity for determination of gemifloxacin.
A sensitive electroanalytical method for determination of gemifloxacin in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode in the presence of CTAB. Solubilized system of different surfactants including SDS, Tween-20 and CTAB were taken for the study of electrochemical behaviour of gemifloxacin at modified electrode. The reduction peak current increases in the presence of CTAB while other surfactants show opposite effect. The modified electrode exhibits catalytic activity, high sensitivity, stability and is applicable over wide range of concentration for the determination of gemifloxacin. The mechanism of electrochemical reduction of gemifloxacin has been proposed on the basis of CV, SWV, DPV and coulometeric techniques. The proposed squarewave voltammetric method shows linearity over the concentration range 2.47–15.5μg/mL. The achieved limits of detection (LOD) and quantification (LOQ) are 0.90ng/mL and 3.0ng/mL respectively. |
| doi_str_mv | 10.1016/j.colsurfb.2010.12.003 |
| format | Article |
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▶ Squarewave method is linear over range 2.47–15.5μg/mL with LOD of 0.90ng/mL. ▶ Proposed method is more sensitive comparison to reported analytical methods. ▶ Use of solubilized system increases sensitivity for determination of gemifloxacin.
A sensitive electroanalytical method for determination of gemifloxacin in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode in the presence of CTAB. Solubilized system of different surfactants including SDS, Tween-20 and CTAB were taken for the study of electrochemical behaviour of gemifloxacin at modified electrode. The reduction peak current increases in the presence of CTAB while other surfactants show opposite effect. The modified electrode exhibits catalytic activity, high sensitivity, stability and is applicable over wide range of concentration for the determination of gemifloxacin. The mechanism of electrochemical reduction of gemifloxacin has been proposed on the basis of CV, SWV, DPV and coulometeric techniques. The proposed squarewave voltammetric method shows linearity over the concentration range 2.47–15.5μg/mL. The achieved limits of detection (LOD) and quantification (LOQ) are 0.90ng/mL and 3.0ng/mL respectively.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2010.12.003</identifier><identifier>PMID: 21177081</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anti-Bacterial Agents - chemistry ; Carbon - chemistry ; carbon nanotubes ; catalytic activity ; cetyltrimethylammonium bromide ; colloids ; Coulometers ; CTAB (cetyltrimethyl ammonium bromide) ; detection limit ; drug formulations ; drugs ; Electrochemistry ; Electrodes ; Fluoroquinolones - chemistry ; Gemifloxacin (GMX) ; Glass - chemistry ; Glassy carbon ; glassy carbon electrode ; Mathematical analysis ; Molecular Structure ; Multi wall carbon nanotubes ; Multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs-GCE) ; Nanotubes, Carbon - chemistry ; Naphthyridines - chemistry ; Particle Size ; polysorbates ; Reduction ; Solubility ; solubilization ; Solubilized systems ; Stability ; Surface Properties ; Surfactants ; Voltammetric determination</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2011-04, Vol.83 (2), p.340-346</ispartof><rights>2010</rights><rights>Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-f0192a8276d092dcad7b14822b0d039dd55a7e2f8e1c72aead40938c84b1118d3</citedby><cites>FETCH-LOGICAL-c392t-f0192a8276d092dcad7b14822b0d039dd55a7e2f8e1c72aead40938c84b1118d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2010.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21177081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jain, Rajeev</creatorcontrib><creatorcontrib>Rather, Jahangir Ahmad</creatorcontrib><title>Voltammetric determination of antibacterial drug gemifloxacin in solubilized systems at multi-walled carbon nanotubes modified glassy carbon electrode</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>[Display omitted]
▶ Squarewave method is linear over range 2.47–15.5μg/mL with LOD of 0.90ng/mL. ▶ Proposed method is more sensitive comparison to reported analytical methods. ▶ Use of solubilized system increases sensitivity for determination of gemifloxacin.
A sensitive electroanalytical method for determination of gemifloxacin in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode in the presence of CTAB. Solubilized system of different surfactants including SDS, Tween-20 and CTAB were taken for the study of electrochemical behaviour of gemifloxacin at modified electrode. The reduction peak current increases in the presence of CTAB while other surfactants show opposite effect. The modified electrode exhibits catalytic activity, high sensitivity, stability and is applicable over wide range of concentration for the determination of gemifloxacin. The mechanism of electrochemical reduction of gemifloxacin has been proposed on the basis of CV, SWV, DPV and coulometeric techniques. The proposed squarewave voltammetric method shows linearity over the concentration range 2.47–15.5μg/mL. The achieved limits of detection (LOD) and quantification (LOQ) are 0.90ng/mL and 3.0ng/mL respectively.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Carbon - chemistry</subject><subject>carbon nanotubes</subject><subject>catalytic activity</subject><subject>cetyltrimethylammonium bromide</subject><subject>colloids</subject><subject>Coulometers</subject><subject>CTAB (cetyltrimethyl ammonium bromide)</subject><subject>detection limit</subject><subject>drug formulations</subject><subject>drugs</subject><subject>Electrochemistry</subject><subject>Electrodes</subject><subject>Fluoroquinolones - chemistry</subject><subject>Gemifloxacin (GMX)</subject><subject>Glass - chemistry</subject><subject>Glassy carbon</subject><subject>glassy carbon electrode</subject><subject>Mathematical analysis</subject><subject>Molecular Structure</subject><subject>Multi wall carbon nanotubes</subject><subject>Multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs-GCE)</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Naphthyridines - chemistry</subject><subject>Particle Size</subject><subject>polysorbates</subject><subject>Reduction</subject><subject>Solubility</subject><subject>solubilization</subject><subject>Solubilized systems</subject><subject>Stability</subject><subject>Surface Properties</subject><subject>Surfactants</subject><subject>Voltammetric determination</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhi0EotPCKxQv2WTwJRMnO1DFTarEAsrWOrFPRh7ZcbEd6PAgPC-OpsMWyZKl39-5-P8JueZsyxnv3hy2Jvq8pGncCraKYsuYfEI2vFeyaWWnnpING4RqlOp2F-Qy5wNjTLRcPScXgnOlWM835M_36AuEgCU5Qy0WTMHNUFycaZwozMWNYKrqwFOblj3dY3CTjw9g3EzrydEvo_PuN1qaj7lgyBQKDYsvrvkF3lfdQBprwxnmWJYRMw3RusnVl72HnI9nAD2akqLFF-TZBD7jy8f7itx9eP_t5lNz--Xj55t3t42RgyjNxPggoBeqs_Wv1oBVI297IUZmmRys3e1AoZh65EYJQLAtG2Rv-nbknPdWXpHXp773Kf5YMBcdXDboPcwYl6xXm2TLWLeraHdCTYo5J5z0fXIB0lFzptdM9EGfM9FrJpoLXTOphdePM5YxoP1Xdg6hAq9OwARRwz65rO--1g5dDUyyYVhnvz0RWL346TDpbBzOBq1L1TFto_vfFn8BVMeusw</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Jain, Rajeev</creator><creator>Rather, Jahangir Ahmad</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20110401</creationdate><title>Voltammetric determination of antibacterial drug gemifloxacin in solubilized systems at multi-walled carbon nanotubes modified glassy carbon electrode</title><author>Jain, Rajeev ; Rather, Jahangir Ahmad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-f0192a8276d092dcad7b14822b0d039dd55a7e2f8e1c72aead40938c84b1118d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Carbon - chemistry</topic><topic>carbon nanotubes</topic><topic>catalytic activity</topic><topic>cetyltrimethylammonium bromide</topic><topic>colloids</topic><topic>Coulometers</topic><topic>CTAB (cetyltrimethyl ammonium bromide)</topic><topic>detection limit</topic><topic>drug formulations</topic><topic>drugs</topic><topic>Electrochemistry</topic><topic>Electrodes</topic><topic>Fluoroquinolones - chemistry</topic><topic>Gemifloxacin (GMX)</topic><topic>Glass - chemistry</topic><topic>Glassy carbon</topic><topic>glassy carbon electrode</topic><topic>Mathematical analysis</topic><topic>Molecular Structure</topic><topic>Multi wall carbon nanotubes</topic><topic>Multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs-GCE)</topic><topic>Nanotubes, Carbon - chemistry</topic><topic>Naphthyridines - chemistry</topic><topic>Particle Size</topic><topic>polysorbates</topic><topic>Reduction</topic><topic>Solubility</topic><topic>solubilization</topic><topic>Solubilized systems</topic><topic>Stability</topic><topic>Surface Properties</topic><topic>Surfactants</topic><topic>Voltammetric determination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jain, Rajeev</creatorcontrib><creatorcontrib>Rather, Jahangir Ahmad</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jain, Rajeev</au><au>Rather, Jahangir Ahmad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Voltammetric determination of antibacterial drug gemifloxacin in solubilized systems at multi-walled carbon nanotubes modified glassy carbon electrode</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>83</volume><issue>2</issue><spage>340</spage><epage>346</epage><pages>340-346</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>[Display omitted]
▶ Squarewave method is linear over range 2.47–15.5μg/mL with LOD of 0.90ng/mL. ▶ Proposed method is more sensitive comparison to reported analytical methods. ▶ Use of solubilized system increases sensitivity for determination of gemifloxacin.
A sensitive electroanalytical method for determination of gemifloxacin in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode in the presence of CTAB. Solubilized system of different surfactants including SDS, Tween-20 and CTAB were taken for the study of electrochemical behaviour of gemifloxacin at modified electrode. The reduction peak current increases in the presence of CTAB while other surfactants show opposite effect. The modified electrode exhibits catalytic activity, high sensitivity, stability and is applicable over wide range of concentration for the determination of gemifloxacin. The mechanism of electrochemical reduction of gemifloxacin has been proposed on the basis of CV, SWV, DPV and coulometeric techniques. The proposed squarewave voltammetric method shows linearity over the concentration range 2.47–15.5μg/mL. The achieved limits of detection (LOD) and quantification (LOQ) are 0.90ng/mL and 3.0ng/mL respectively.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21177081</pmid><doi>10.1016/j.colsurfb.2010.12.003</doi><tpages>7</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - chemistry Carbon - chemistry carbon nanotubes catalytic activity cetyltrimethylammonium bromide colloids Coulometers CTAB (cetyltrimethyl ammonium bromide) detection limit drug formulations drugs Electrochemistry Electrodes Fluoroquinolones - chemistry Gemifloxacin (GMX) Glass - chemistry Glassy carbon glassy carbon electrode Mathematical analysis Molecular Structure Multi wall carbon nanotubes Multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs-GCE) Nanotubes, Carbon - chemistry Naphthyridines - chemistry Particle Size polysorbates Reduction Solubility solubilization Solubilized systems Stability Surface Properties Surfactants Voltammetric determination |
| title | Voltammetric determination of antibacterial drug gemifloxacin in solubilized systems at multi-walled carbon nanotubes modified glassy carbon electrode |
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