Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis
Psoriasis is a chronic inflammatory skin disease affecting 2-5% of the population worldwide and it severely affects patient quality of life. In this study, an amphiphilic zinc phthalocyanine polymer conjugate (ZPB) was synthesized, in which zinc phthalocyanine (ZnPc) was conjugated with the poly(eth...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-04, Vol.128, p.405-409 |
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| creator | Jin, Yiguang Zhang, Xiaohan Zhang, Baolei Kang, Hongxiang Du, Lina Li, Miao |
| description | Psoriasis is a chronic inflammatory skin disease affecting 2-5% of the population worldwide and it severely affects patient quality of life. In this study, an amphiphilic zinc phthalocyanine polymer conjugate (ZPB) was synthesized, in which zinc phthalocyanine (ZnPc) was conjugated with the poly(ethylene glycol) (PEG) chain of Brij 58. ZPB showed two maximum UV-vis absorption wavelengths, 348 nm and 678 nm. A monomolecular micelle of ZPB formed in water with a mean size of 25 nm and zeta potential of -15 mV. The nanostructures aggregated into cloudy precipitates, which were easily dispersed. The nanostructure showed the shell-core structure with the ZnPc segments as the core and the PEG chains as the shell. The anti-psoriasis effect of the ZPB nanostructure was explored using a guinea pig psoriasis model. After comparing the anti-psoriasis effects of saline, light alone, ZPB alone, and the combination of light and ZPB, the combination of light and ZPB showed the best photodynamic therapy of psoriasis based on the light excitation of the photosensitizer ZPB and the psoriasis was nearly cured according to the histopathological investigation. The ZPB nanostructure is a promising anti-psoriasis nanomedicine based on photodynamic therapy. |
| doi_str_mv | 10.1016/j.colsurfb.2015.02.038 |
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In this study, an amphiphilic zinc phthalocyanine polymer conjugate (ZPB) was synthesized, in which zinc phthalocyanine (ZnPc) was conjugated with the poly(ethylene glycol) (PEG) chain of Brij 58. ZPB showed two maximum UV-vis absorption wavelengths, 348 nm and 678 nm. A monomolecular micelle of ZPB formed in water with a mean size of 25 nm and zeta potential of -15 mV. The nanostructures aggregated into cloudy precipitates, which were easily dispersed. The nanostructure showed the shell-core structure with the ZnPc segments as the core and the PEG chains as the shell. The anti-psoriasis effect of the ZPB nanostructure was explored using a guinea pig psoriasis model. After comparing the anti-psoriasis effects of saline, light alone, ZPB alone, and the combination of light and ZPB, the combination of light and ZPB showed the best photodynamic therapy of psoriasis based on the light excitation of the photosensitizer ZPB and the psoriasis was nearly cured according to the histopathological investigation. The ZPB nanostructure is a promising anti-psoriasis nanomedicine based on photodynamic therapy.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2015.02.038</identifier><identifier>PMID: 25766924</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Animals ; Biomaterials ; Cetomacrogol - chemistry ; Chains ; Conjugates ; Disease Models, Animal ; Drug Carriers ; Glycols ; Guinea Pigs ; Humans ; Indoles - agonists ; Indoles - chemistry ; Indoles - pharmacology ; Male ; Micelles ; Nanostructure ; Nanostructures - chemistry ; Nanostructures - ultrastructure ; Organometallic Compounds - agonists ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Patients ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - agonists ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacology ; Psoriasis - drug therapy ; Psoriasis - pathology ; Ultraviolet Rays ; Water - chemistry ; Zinc</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2015-04, Vol.128, p.405-409</ispartof><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-b4cdddaab3da0ef8c663fffd838848faf0945cee49fed6e6f9a891c7dd050cfe3</citedby><cites>FETCH-LOGICAL-c447t-b4cdddaab3da0ef8c663fffd838848faf0945cee49fed6e6f9a891c7dd050cfe3</cites><orcidid>0000-0002-3528-1397</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25766924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Yiguang</creatorcontrib><creatorcontrib>Zhang, Xiaohan</creatorcontrib><creatorcontrib>Zhang, Baolei</creatorcontrib><creatorcontrib>Kang, Hongxiang</creatorcontrib><creatorcontrib>Du, Lina</creatorcontrib><creatorcontrib>Li, Miao</creatorcontrib><title>Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>Psoriasis is a chronic inflammatory skin disease affecting 2-5% of the population worldwide and it severely affects patient quality of life. In this study, an amphiphilic zinc phthalocyanine polymer conjugate (ZPB) was synthesized, in which zinc phthalocyanine (ZnPc) was conjugated with the poly(ethylene glycol) (PEG) chain of Brij 58. ZPB showed two maximum UV-vis absorption wavelengths, 348 nm and 678 nm. A monomolecular micelle of ZPB formed in water with a mean size of 25 nm and zeta potential of -15 mV. The nanostructures aggregated into cloudy precipitates, which were easily dispersed. The nanostructure showed the shell-core structure with the ZnPc segments as the core and the PEG chains as the shell. The anti-psoriasis effect of the ZPB nanostructure was explored using a guinea pig psoriasis model. After comparing the anti-psoriasis effects of saline, light alone, ZPB alone, and the combination of light and ZPB, the combination of light and ZPB showed the best photodynamic therapy of psoriasis based on the light excitation of the photosensitizer ZPB and the psoriasis was nearly cured according to the histopathological investigation. The ZPB nanostructure is a promising anti-psoriasis nanomedicine based on photodynamic therapy.</description><subject>Animals</subject><subject>Biomaterials</subject><subject>Cetomacrogol - chemistry</subject><subject>Chains</subject><subject>Conjugates</subject><subject>Disease Models, Animal</subject><subject>Drug Carriers</subject><subject>Glycols</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Indoles - agonists</subject><subject>Indoles - chemistry</subject><subject>Indoles - pharmacology</subject><subject>Male</subject><subject>Micelles</subject><subject>Nanostructure</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - ultrastructure</subject><subject>Organometallic Compounds - agonists</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Patients</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - agonists</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - pathology</subject><subject>Ultraviolet Rays</subject><subject>Water - chemistry</subject><subject>Zinc</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkbtu3DAQRYnAQbx28guGSjeS-RIfZWD4EcBImqQmZslhVgtJVEipkL8-WvjRJsAAtzn3TnEIuWK0YZSpm2PjU1-WHPcNp6xtKG-oMB_IjhktaimUPiM7armutVbtObko5Ugp5ZLpT-Sct1opy-WO9N9hTGXOi5-XjKVKsYKxgmE6dNv1na-eu9FX02E-QJ_8CmM3YjWlfh0wVz6Nx-U3zFjFlDcozSmsIwxbbT5ghmk9DU4l5Q5KVz6TjxH6gl9e85L8ur_7eftYP_14-Hb79an2Uuq53ksfQgDYiwAUo_FKiRhjMMIYaSJEamXrEaWNGBSqaMFY5nUItKU-orgk1y-7U05_FiyzG7rise9hxLQUx7SmQhht2_9ABTeCKmb_jSrNFeOtZRuqXlCfUykZo5tyN0BeHaPu5M8d3Zs_d_LnKHebv6149fpj2Q8Y3mtvwsRfUiGdqw</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Jin, Yiguang</creator><creator>Zhang, Xiaohan</creator><creator>Zhang, Baolei</creator><creator>Kang, Hongxiang</creator><creator>Du, Lina</creator><creator>Li, Miao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-3528-1397</orcidid></search><sort><creationdate>20150401</creationdate><title>Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis</title><author>Jin, Yiguang ; Zhang, Xiaohan ; Zhang, Baolei ; Kang, Hongxiang ; Du, Lina ; Li, Miao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-b4cdddaab3da0ef8c663fffd838848faf0945cee49fed6e6f9a891c7dd050cfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biomaterials</topic><topic>Cetomacrogol - chemistry</topic><topic>Chains</topic><topic>Conjugates</topic><topic>Disease Models, Animal</topic><topic>Drug Carriers</topic><topic>Glycols</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Indoles - agonists</topic><topic>Indoles - chemistry</topic><topic>Indoles - pharmacology</topic><topic>Male</topic><topic>Micelles</topic><topic>Nanostructure</topic><topic>Nanostructures - chemistry</topic><topic>Nanostructures - ultrastructure</topic><topic>Organometallic Compounds - agonists</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Patients</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - agonists</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - pathology</topic><topic>Ultraviolet Rays</topic><topic>Water - chemistry</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Yiguang</creatorcontrib><creatorcontrib>Zhang, Xiaohan</creatorcontrib><creatorcontrib>Zhang, Baolei</creatorcontrib><creatorcontrib>Kang, Hongxiang</creatorcontrib><creatorcontrib>Du, Lina</creatorcontrib><creatorcontrib>Li, Miao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Yiguang</au><au>Zhang, Xiaohan</au><au>Zhang, Baolei</au><au>Kang, Hongxiang</au><au>Du, Lina</au><au>Li, Miao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>128</volume><spage>405</spage><epage>409</epage><pages>405-409</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>Psoriasis is a chronic inflammatory skin disease affecting 2-5% of the population worldwide and it severely affects patient quality of life. In this study, an amphiphilic zinc phthalocyanine polymer conjugate (ZPB) was synthesized, in which zinc phthalocyanine (ZnPc) was conjugated with the poly(ethylene glycol) (PEG) chain of Brij 58. ZPB showed two maximum UV-vis absorption wavelengths, 348 nm and 678 nm. A monomolecular micelle of ZPB formed in water with a mean size of 25 nm and zeta potential of -15 mV. The nanostructures aggregated into cloudy precipitates, which were easily dispersed. The nanostructure showed the shell-core structure with the ZnPc segments as the core and the PEG chains as the shell. The anti-psoriasis effect of the ZPB nanostructure was explored using a guinea pig psoriasis model. After comparing the anti-psoriasis effects of saline, light alone, ZPB alone, and the combination of light and ZPB, the combination of light and ZPB showed the best photodynamic therapy of psoriasis based on the light excitation of the photosensitizer ZPB and the psoriasis was nearly cured according to the histopathological investigation. The ZPB nanostructure is a promising anti-psoriasis nanomedicine based on photodynamic therapy.</abstract><cop>Netherlands</cop><pmid>25766924</pmid><doi>10.1016/j.colsurfb.2015.02.038</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3528-1397</orcidid></addata></record> |
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| subjects | Animals Biomaterials Cetomacrogol - chemistry Chains Conjugates Disease Models, Animal Drug Carriers Glycols Guinea Pigs Humans Indoles - agonists Indoles - chemistry Indoles - pharmacology Male Micelles Nanostructure Nanostructures - chemistry Nanostructures - ultrastructure Organometallic Compounds - agonists Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Patients Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - agonists Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Psoriasis - drug therapy Psoriasis - pathology Ultraviolet Rays Water - chemistry Zinc |
| title | Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis |
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