Highly sensitive detection of DNA methylation levels by using a quantum dot-based FRET method

DNA methylation is the most frequently studied epigenetic modification that is strongly involved in genomic stability and cellular plasticity. Aberrant changes in DNA methylation status are ubiquitous in human cancer and the detection of these changes can be informative for cancer diagnosis. Herein,...

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Veröffentlicht in:	Nanoscale 2015-11, Vol.7 (41), p.17547-17555
Hauptverfasser:	Ma, Yunfei, Zhang, Honglian, Liu, Fangming, Wu, Zhenhua, Lu, Shaohua, Jin, Qinghui, Zhao, Jianlong, Zhong, Xinhua, Mao, Hongju
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Amplification Cancer Carbocyanines - chemistry Cell Line, Tumor Deoxyribonucleic acid DNA Methylation DNA, Neoplasm - metabolism Enzymes Fluorescence Fluorescence Resonance Energy Transfer - methods Fretting Genes, Tumor Suppressor Human Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Methylation Quantum Dots - chemistry Qunatum dots
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