Excitatory amino acid beta-N-methylamino-L-alanine is a putative environmental neurotoxin
The amino acid beta-N-methylamino-L-alanine (L-BMAA) has been associated with the amyotrophic lateral sclerosis/parkinsonismdementia complex in three distinct western Pacific populations. The putative neurotoxin is produced by cyanobacteria, which live symbiotically in the roots of cycad trees. L-BM...
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Veröffentlicht in: | Journal of the Serbian Chemical Society 2011, Vol.76 (4), p.479-490 |
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container_title | Journal of the Serbian Chemical Society |
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creator | Lopicic, Srdjan Stanojevic, Marija Dhruba, Pathak Pavlovic, Dragan Prostran, Milica Nedeljkov, Vladimir |
description | The amino acid beta-N-methylamino-L-alanine (L-BMAA) has been associated with
the amyotrophic lateral sclerosis/parkinsonismdementia complex in three
distinct western Pacific populations. The putative neurotoxin is produced by
cyanobacteria, which live symbiotically in the roots of cycad trees. L-BMAA
was thought to be a threat only to those few populations whose diet and
medicines rely heavily on cycad seeds. However, the recent discovery that
cyanobacteria from diverse terrestrial, freshwater, and saltwater ecosystems
around the world produce the toxin requires a reassessment of whether it
poses a larger health threat. Therefore, it is proposed that monitoring
L-BMAA levels in cyanobacteria-contaminated water supplies might be prudent.
nema |
doi_str_mv | 10.2298/JSC100629047L |
format | Article |
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the amyotrophic lateral sclerosis/parkinsonismdementia complex in three
distinct western Pacific populations. The putative neurotoxin is produced by
cyanobacteria, which live symbiotically in the roots of cycad trees. L-BMAA
was thought to be a threat only to those few populations whose diet and
medicines rely heavily on cycad seeds. However, the recent discovery that
cyanobacteria from diverse terrestrial, freshwater, and saltwater ecosystems
around the world produce the toxin requires a reassessment of whether it
poses a larger health threat. Therefore, it is proposed that monitoring
L-BMAA levels in cyanobacteria-contaminated water supplies might be prudent.
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the amyotrophic lateral sclerosis/parkinsonismdementia complex in three
distinct western Pacific populations. The putative neurotoxin is produced by
cyanobacteria, which live symbiotically in the roots of cycad trees. L-BMAA
was thought to be a threat only to those few populations whose diet and
medicines rely heavily on cycad seeds. However, the recent discovery that
cyanobacteria from diverse terrestrial, freshwater, and saltwater ecosystems
around the world produce the toxin requires a reassessment of whether it
poses a larger health threat. Therefore, it is proposed that monitoring
L-BMAA levels in cyanobacteria-contaminated water supplies might be prudent.
nema</description><subject>Amino acids</subject><subject>Cyanobacteria</subject><subject>Diets</subject><subject>Ecosystems</subject><subject>Monitoring</subject><subject>Populations</subject><subject>Toxins</subject><subject>Water supplies</subject><issn>0352-5139</issn><issn>1820-7421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpVkD1PwzAYhC0EEqUwsntkMfgjjpMRVYWCIhiAgSl6k7wRRoldbKdq_z2FsjCddHrudDpCLgW_lrIsbh5fFoLzXJY8M9URmYlCcmYyKY7JjCstmRaqPCVnMX5yLrVW2Yy8L7etTZB82FEYrfMUWtvRBhOwJzZi-tgNvz6rGAzgrENqIwW6nvYpu0GKbmODdyO6BAN1OAWf_Na6c3LSwxDx4k_n5O1u-bpYser5_mFxW7FW8TKx3OQFCCNMqTT0Xac4GMEbVHkrodOQ6R503vScI-Romsw0sgdjRNFCr2Wp5uTq0LsO_mvCmOrRxhaH_Vj0U6yFMVxJVeZmj7ID2gYfY8C-Xgc7QtjVgtc_F9b_LlTfYQplFA</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Lopicic, Srdjan</creator><creator>Stanojevic, Marija</creator><creator>Dhruba, Pathak</creator><creator>Pavlovic, Dragan</creator><creator>Prostran, Milica</creator><creator>Nedeljkov, Vladimir</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>2011</creationdate><title>Excitatory amino acid beta-N-methylamino-L-alanine is a putative environmental neurotoxin</title><author>Lopicic, Srdjan ; Stanojevic, Marija ; Dhruba, Pathak ; Pavlovic, Dragan ; Prostran, Milica ; Nedeljkov, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-6768a1717935afdd30a710be36c2ad5a45fa56bf00ea6e7b47b2fa7718caf5293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amino acids</topic><topic>Cyanobacteria</topic><topic>Diets</topic><topic>Ecosystems</topic><topic>Monitoring</topic><topic>Populations</topic><topic>Toxins</topic><topic>Water supplies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopicic, Srdjan</creatorcontrib><creatorcontrib>Stanojevic, Marija</creatorcontrib><creatorcontrib>Dhruba, Pathak</creatorcontrib><creatorcontrib>Pavlovic, Dragan</creatorcontrib><creatorcontrib>Prostran, Milica</creatorcontrib><creatorcontrib>Nedeljkov, Vladimir</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of the Serbian Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopicic, Srdjan</au><au>Stanojevic, Marija</au><au>Dhruba, Pathak</au><au>Pavlovic, Dragan</au><au>Prostran, Milica</au><au>Nedeljkov, Vladimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excitatory amino acid beta-N-methylamino-L-alanine is a putative environmental neurotoxin</atitle><jtitle>Journal of the Serbian Chemical Society</jtitle><date>2011</date><risdate>2011</risdate><volume>76</volume><issue>4</issue><spage>479</spage><epage>490</epage><pages>479-490</pages><issn>0352-5139</issn><eissn>1820-7421</eissn><abstract>The amino acid beta-N-methylamino-L-alanine (L-BMAA) has been associated with
the amyotrophic lateral sclerosis/parkinsonismdementia complex in three
distinct western Pacific populations. The putative neurotoxin is produced by
cyanobacteria, which live symbiotically in the roots of cycad trees. L-BMAA
was thought to be a threat only to those few populations whose diet and
medicines rely heavily on cycad seeds. However, the recent discovery that
cyanobacteria from diverse terrestrial, freshwater, and saltwater ecosystems
around the world produce the toxin requires a reassessment of whether it
poses a larger health threat. Therefore, it is proposed that monitoring
L-BMAA levels in cyanobacteria-contaminated water supplies might be prudent.
nema</abstract><doi>10.2298/JSC100629047L</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
subjects | Amino acids Cyanobacteria Diets Ecosystems Monitoring Populations Toxins Water supplies |
title | Excitatory amino acid beta-N-methylamino-L-alanine is a putative environmental neurotoxin |
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