Excitatory amino acid beta-N-methylamino-L-alanine is a putative environmental neurotoxin

The amino acid beta-N-methylamino-L-alanine (L-BMAA) has been associated with the amyotrophic lateral sclerosis/parkinsonismdementia complex in three distinct western Pacific populations. The putative neurotoxin is produced by cyanobacteria, which live symbiotically in the roots of cycad trees. L-BM...

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Veröffentlicht in:Journal of the Serbian Chemical Society 2011, Vol.76 (4), p.479-490
Hauptverfasser: Lopicic, Srdjan, Stanojevic, Marija, Dhruba, Pathak, Pavlovic, Dragan, Prostran, Milica, Nedeljkov, Vladimir
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container_end_page 490
container_issue 4
container_start_page 479
container_title Journal of the Serbian Chemical Society
container_volume 76
creator Lopicic, Srdjan
Stanojevic, Marija
Dhruba, Pathak
Pavlovic, Dragan
Prostran, Milica
Nedeljkov, Vladimir
description The amino acid beta-N-methylamino-L-alanine (L-BMAA) has been associated with the amyotrophic lateral sclerosis/parkinsonismdementia complex in three distinct western Pacific populations. The putative neurotoxin is produced by cyanobacteria, which live symbiotically in the roots of cycad trees. L-BMAA was thought to be a threat only to those few populations whose diet and medicines rely heavily on cycad seeds. However, the recent discovery that cyanobacteria from diverse terrestrial, freshwater, and saltwater ecosystems around the world produce the toxin requires a reassessment of whether it poses a larger health threat. Therefore, it is proposed that monitoring L-BMAA levels in cyanobacteria-contaminated water supplies might be prudent. nema
doi_str_mv 10.2298/JSC100629047L
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subjects Amino acids
Cyanobacteria
Diets
Ecosystems
Monitoring
Populations
Toxins
Water supplies
title Excitatory amino acid beta-N-methylamino-L-alanine is a putative environmental neurotoxin
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