Human epidermal growth factor receptor-2 antibodies enhance the specificity and anticancer activity of light-sensitive doxorubicin-labeled liposomes

Abstract Antibody-mediated targeting therapy has been successful in treating patients with cancers by improving the specificity and clinical efficacy. In this study, we developed a human epidermal growth factor receptor-2 (HER2) antibody-conjugated drug delivery system, using near-infrared (NIR) lig...

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Veröffentlicht in:	Biomaterials 2015-07, Vol.57, p.1-11
Hauptverfasser:	Li, Qingpo, Tang, Qin, Zhang, Peizun, Wang, Zuhua, Zhao, Tiantian, Zhou, Jialin, Li, Hongrui, Ding, Qian, Li, Wei, Hu, Fuqiang, Du, Yongzhong, Yuan, Hong, Chen, Shuqing, Gao, Jianqing, Zhan, Jinbiao, You, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - therapeutic use Antibody-mediated targeted delivery Biocompatibility Biomedical materials Cell Line, Tumor Delayed-Action Preparations - chemistry Dentistry Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Doxorubicin - chemistry Drug Delivery Systems Effectiveness Female HER2 antibody Hollow gold nanospheres Humans Hyperthermia, Induced Immunoconjugates - chemistry Immunoconjugates - therapeutic use Light Light-sensitive liposomes Liposomes Mice Mice, Nude Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovary - drug effects Ovary - metabolism Ovary - pathology Phototherapy Photothermal-chemotherapy Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - metabolism Surgical implants Toxicity Tumors
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