Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: Antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies

Polymyxins are a group of antibiotics with a common structure of a cyclic peptide with a long hydrophobic tail. Polymyxin B sulphate (PLX) has cationic charge, which is an obstacle for the efficient loading into Solid Lipid Nanoparticles (SLN). In the present paper, we describe an innovative method...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-05, Vol.129, p.191-197
Hauptverfasser:	Severino, Patrícia, Chaud, Marco V., Shimojo, Andrea, Antonini, Danilo, Lancelloti, Marcelo, Santana, Maria Helena A., Souto, Eliana B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates - chemistry Animals Anti-Bacterial Agents - pharmacology Antibiotics Cell Survival - drug effects Cells, Cultured Cross-Linking Reagents - chemistry Crosslinking Drug Carriers - chemistry Drug Carriers - pharmacology Drug delivery Drug Resistance, Microbial - drug effects Drugs Fibroblasts - cytology Fibroblasts - drug effects Glucuronic Acid - chemistry Hexuronic Acids - chemistry High pressure homogenization Homogenization Homogenizing Humans Hydrophobic and Hydrophilic Interactions Keratinocytes - cytology Keratinocytes - drug effects Lipids Lipids - chemistry Mice Nanoparticles - chemistry NIH 3T3 Cells Particle Size Polymyxin B - pharmacology Polymyxin B sulphate Pseudomonas aeruginosa Sodium alginate Solid lipid nanoparticles Strain Viability
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