Newly identified interfibrillar collagen crosslinking suppresses cell proliferation and remodelling

Abstract Copper is becoming recognised as a key cation in a variety of biological processes. Copper chelation has been studied as a potential anti-angiogenic strategy for arresting tumour growth. Conversely the delivery of copper ions and complexes in vivo can elicit a pro-angiogenic effect. Previou...

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Veröffentlicht in:	Biomaterials 2015-06, Vol.54, p.126-135
Hauptverfasser:	Marelli, Benedetto, Le Nihouannen, Damien, Hacking, S. Adam, Tran, Simon, Li, Jingjing, Murshed, Monzur, Doillon, Charles J, Ghezzi, Chiara E, Zhang, Yu Ling, Nazhat, Showan N, Barralet, Jake E
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Age Biomedical materials Bone Cell Differentiation - physiology Cell Proliferation - physiology Cells, Cultured Collagen Collagens Copper Copper - chemistry Copper - metabolism Cross-Linking Reagents - chemistry Cross-Linking Reagents - metabolism Crosslinking Dentistry Deposition Extracellular Matrix - chemistry Extracellular Matrix - metabolism Fibrillar Collagens - chemistry Fibrillar Collagens - metabolism Fibroblasts Fibroblasts - cytology Fibroblasts - physiology Humans Matrix Metalloproteinases - metabolism Surgical implants
Online-Zugang:	Volltext
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