Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts

The aim of present study was to prepare nanometer sized particles of gelatin via water-in-oil microemulsion system for drug and gene delivery applications. In this study, cross-linked gelatin nanoparticles encapsulating a fluorescent marker molecule fluorescein isothiocyanate-dextran (FITC-Dex, Mol....

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Veröffentlicht in:	Journal of controlled release 2004-03, Vol.95 (2), p.197-207
Hauptverfasser:	Gupta, Ajay Kumar, Gupta, Mona, Yarwood, Stephen J., Curtis, Adam S.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adhesiveness Biological and medical sciences Cell Adhesion - drug effects Cell Survival - drug effects Cells, Cultured Chemical Phenomena Chemistry, Physical Cross-Linking Reagents Cytoskeleton Cytoskeleton - drug effects Cytoskeleton - ultrastructure Cytotoxicity Dextrans Drug Compounding Drug delivery Emulsions Excipients Fibroblasts - drug effects Fibroblasts - ultrastructure Fluorescein-5-isothiocyanate - analogs & derivatives Gelatin Gelatin - administration & dosage Gelatin - metabolism Gelatin - pharmacology General pharmacology Humans Medical sciences Microscopy, Electron Microscopy, Electron, Scanning Microscopy, Fluorescence Microspheres Nanoparticles Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Tubulin - metabolism
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