Biodegradable Nanotopography Combined with Neurotrophic Signals Enhances Contact Guidance and Neuronal Differentiation of Human Neural Stem Cells

Biophysical cues provided by nanotopographical surfaces have been used as stimuli to guide neurite extension and regulate neural stem cell (NSC) differentiation. Here, we fabricated biodegradable polymer substrates with nanoscale topography for enhancing human NSC (hNSC) differentiation and guided n...

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Veröffentlicht in:	Macromolecular bioscience 2015-10, Vol.15 (10), p.1348-1356
Hauptverfasser:	Yang, Kisuk, Park, Esther, Lee, Jong Seung, Kim, Il-Sun, Hong, Kwonho, Park, Kook In, Cho, Seung-Woo, Yang, Hee Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradability biodegradable nanotopography Biomarkers - metabolism Cell Differentiation - drug effects Contact contact guidance Cues Cytoskeleton - drug effects Cytoskeleton - metabolism Differentiation focal adhesion Focal Adhesions - drug effects Focal Adhesions - metabolism Gene Expression Regulation - drug effects Human human neural stem cells Humans Immobilization Lactic Acid - chemistry Nanoparticles - chemistry Nanostructure nerve growth factor Nerve Growth Factors - pharmacology Neural Stem Cells - cytology Neural Stem Cells - drug effects Neurites - drug effects Neurites - metabolism Neurons - cytology Neurons - drug effects Polyglycolic Acid - chemistry Stem cells Surface Properties Water - chemistry
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