Combining Biological Networks to Predict Genetic Interactions

Genetic interactions define overlapping functions and compensatory pathways. In particular, synthetic sick or lethal (SSL) genetic interactions are important for understanding how an organism tolerates random mutation, i.e., genetic robustness. Comprehensive identification of SSL relationships remai...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-11, Vol.101 (44), p.15682-15687
Hauptverfasser:	Wong, Sharyl L., Zhang, Lan V., Amy H. Y. Tong, Li, Zhijian, Goldberg, Debra S., King, Oliver D., Lesage, Guillaume, Vidal, Marc, Andrews, Brenda, Bussey, Howard, Boone, Charles, Roth, Frederick P., Kleckner, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Biology Databases, Genetic Decision Trees Drug interactions Genes Genetic mutation Genetics Genomes Genotype Human genetics Medical genetics Models, Genetic Models, Statistical Mutation Phenotype Phenotypes Plant interaction Saccharomyces cerevisiae
Online-Zugang:	Volltext
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