The Incidence of Kaposi Sarcoma Among Injection Drug Users With AIDS in the United States
Some studies report increased prevalence of human herpesvirus 8 (HHV-8), the causative agent of Kaposi sarcoma (KS), among injection drug users (IDUs), suggesting that HHV-8 may be transmitted through blood-borne or other exposures common in this population. Since an elevated HHV-8 prevalence in IDU...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2004-10, Vol.37 (2), p.1282-1287 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | Atkinson, Jonnae O Biggar, Robert J Goedert, James J Engels, Eric A |
| description | Some studies report increased prevalence of human herpesvirus 8 (HHV-8), the causative agent of Kaposi sarcoma (KS), among injection drug users (IDUs), suggesting that HHV-8 may be transmitted through blood-borne or other exposures common in this population. Since an elevated HHV-8 prevalence in IDUs would likely lead to increased KS incidence, KS incidence was studied in IDUs and non-IDU’s with AIDS. AIDS-related KS cases were identified using linked US AIDS and cancer registry data for 25,891 women, 47,782 heterosexual men, and 90,616 men who have sex with men (MSM). KS arose in 7099 persons with AIDS. KS incidence was highest for MSM (5.7 per 100 person-years), substantially lower for heterosexual men (0.7 per 100 person-years), and lowest for women (0.4 per 100 person-years). After adjustment for age, race, registry location, and year of AIDS onset, relative risks for KS associated with injection drug use were 1.3 (95% CI, 0.9–1.8) among women, 1.1 (0.7–1.6) among heterosexual men, and 0.9 (0.8–0.9) among MSM. It is concluded that injection drug use was not associated with an increased risk of AIDS-related KS. Thus, these data suggest that IDUs’ risk of acquiring HHV-8, through needle sharing or other behaviors related to injection drug use, is low. |
| doi_str_mv | 10.1097/01.qai.0000120807.43677.b6 |
| format | Article |
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Since an elevated HHV-8 prevalence in IDUs would likely lead to increased KS incidence, KS incidence was studied in IDUs and non-IDU’s with AIDS. AIDS-related KS cases were identified using linked US AIDS and cancer registry data for 25,891 women, 47,782 heterosexual men, and 90,616 men who have sex with men (MSM). KS arose in 7099 persons with AIDS. KS incidence was highest for MSM (5.7 per 100 person-years), substantially lower for heterosexual men (0.7 per 100 person-years), and lowest for women (0.4 per 100 person-years). After adjustment for age, race, registry location, and year of AIDS onset, relative risks for KS associated with injection drug use were 1.3 (95% CI, 0.9–1.8) among women, 1.1 (0.7–1.6) among heterosexual men, and 0.9 (0.8–0.9) among MSM. It is concluded that injection drug use was not associated with an increased risk of AIDS-related KS. 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Since an elevated HHV-8 prevalence in IDUs would likely lead to increased KS incidence, KS incidence was studied in IDUs and non-IDU’s with AIDS. AIDS-related KS cases were identified using linked US AIDS and cancer registry data for 25,891 women, 47,782 heterosexual men, and 90,616 men who have sex with men (MSM). KS arose in 7099 persons with AIDS. KS incidence was highest for MSM (5.7 per 100 person-years), substantially lower for heterosexual men (0.7 per 100 person-years), and lowest for women (0.4 per 100 person-years). After adjustment for age, race, registry location, and year of AIDS onset, relative risks for KS associated with injection drug use were 1.3 (95% CI, 0.9–1.8) among women, 1.1 (0.7–1.6) among heterosexual men, and 0.9 (0.8–0.9) among MSM. It is concluded that injection drug use was not associated with an increased risk of AIDS-related KS. Thus, these data suggest that IDUs’ risk of acquiring HHV-8, through needle sharing or other behaviors related to injection drug use, is low.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Disease transmission</subject><subject>Drug use</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health risk assessment</subject><subject>Herpes viruses</subject><subject>Herpesvirus 8, Human - isolation & purification</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - immunology</subject><subject>Human herpesvirus 8</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Sarcoma, Kaposi - epidemiology</subject><subject>Sarcoma, Kaposi - etiology</subject><subject>Sarcoma, Kaposi - virology</subject><subject>Studies</subject><subject>Substance Abuse, Intravenous - complications</subject><subject>United States - epidemiology</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtr3DAQgE1padKkf6GIQHOzq8dIsnpbkj6WBHLYLKUnIdtyVlvb2kgyof--2u7CQuYyM_DNg68orgiuCFbyCybVs3EVzkEorrGsgAkpq0a8Kc6JAihlXcPbXHPKSyCMnxUfYtxmXACo98UZ4azmkonz4vfjxqLl1LrOTq1Fvkd3ZuejQysTWj8atBj99JSJrW2T8xO6DfMTWkcbIvrl0gYtlrcr5CaU8p715JLt0CqZZONl8a43Q7Qfj_miWH__9njzs7x_-LG8WdyXLcdYlbUA0XSk50KYujEYOqEEk4qYvhGdoAaUrAEocFA91MzKRhjc0o72dUOYZRfF9WHvLvjn2cakRxdbOwxmsn6OmkiJMaMyg1evwK2fw5R_05QxQRURNENfD1AbfIzB9noX3GjCX02w3tvXmOhsX5_s6__2dSPy8KfjhbkZbXcaPerOwOcjYGJrhj6YbD6eOEEAMw6ZgwP34oeUVf8Z5hcb9MaaIW30_rBgDEqKMZDc4XL_jWL_AKcUmxo</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Atkinson, Jonnae O</creator><creator>Biggar, Robert J</creator><creator>Goedert, James J</creator><creator>Engels, Eric A</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>20041001</creationdate><title>The Incidence of Kaposi Sarcoma Among Injection Drug Users With AIDS in the United States</title><author>Atkinson, Jonnae O ; Biggar, Robert J ; Goedert, James J ; Engels, Eric A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5009-8646bd1f566a8ba04d6963791afb6d62a49784424549f483e7b6a0c2d2f8b13e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Disease transmission</topic><topic>Drug use</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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| issn | 1525-4135 1944-7884 |
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| subjects | Acquired immune deficiency syndrome Adult Aged AIDS AIDS-Related Opportunistic Infections - epidemiology Biological and medical sciences Disease transmission Drug use Epidemiology Female Fundamental and applied biological sciences. Psychology Health risk assessment Herpes viruses Herpesvirus 8, Human - isolation & purification HIV Infections - complications HIV Infections - immunology Human herpesvirus 8 Human viral diseases Humans Incidence Infections Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Sarcoma, Kaposi - epidemiology Sarcoma, Kaposi - etiology Sarcoma, Kaposi - virology Studies Substance Abuse, Intravenous - complications United States - epidemiology Viral diseases Virology |
| title | The Incidence of Kaposi Sarcoma Among Injection Drug Users With AIDS in the United States |
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