Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice

The hydrophilic poly[ N-(2-hydroxypropyl)methacrylamide] (PHPMA) was used for RNase A or BS-RNase modification to prevent their degradation in bloodstream or fast elimination. Two PHPMA chains (classic and star-like) were synthesized and their conjugates with both enzymes were tested on the CD-1 nud...

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Veröffentlicht in:	Journal of controlled release 2004-02, Vol.95 (1), p.83-92
Hauptverfasser:	PouC̆ková, P, Zadinová, M, Hloušková, D, Strohalm, J, Plocová, D, Špunda, M, Olejár, T, Zitko, M, Matoušek, J, Ulbrich, K, Souček, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - immunology Antitumor activity Biological and medical sciences BS-RNase Cattle Cell Division - drug effects Enzyme-Linked Immunosorbent Assay Female General pharmacology Humans Injections, Intraperitoneal Injections, Intravenous Medical sciences Methacrylates Mice Mice, Nude Neoplasm Transplantation Neuroblastoma - drug therapy Ovarian Neoplasms - drug therapy Pancreas - enzymology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymer conjugates Polymers Pregnancy Ribonuclease, Pancreatic - administration & dosage Ribonuclease, Pancreatic - immunology Ribonuclease, Pancreatic - pharmacology Ribonucleases - administration & dosage Ribonucleases - immunology Ribonucleases - pharmacology RNase A Semen - enzymology Spermatogenesis - drug effects Teratogens - pharmacology Tumor Cells, Cultured
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