CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers

Abstract In addition to direct effect on tumor cells, the tumor-promoting activity of CCL2 has been ascribed to its role in chemoattracting tumor-associated macrophages. However it is unclear whether CCL2 also attracts other immune regulatory cells during tumor development. In this study, we confirm...

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Veröffentlicht in:	Cancer letters 2007-07, Vol.252 (1), p.86-92
Hauptverfasser:	Huang, Bo, Lei, Zhang, Zhao, Jie, Gong, Wei, Liu, Jinwen, Chen, Zhenyong, Liu, Yi, Li, Dong, Yuan, Ye, Zhang, Gui-Mei, Feng, Zuo-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antibodies, Blocking - pharmacology Cancer CCL2 CCR2 Cell Movement Chemokine CCL2 - antagonists & inhibitors Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokines Hematology, Oncology and Palliative Medicine Humans Melanoma Mice Mice, Mutant Strains Migration Molecular weight MSC Myeloid Cells - immunology Neoplasms - immunology Patients Receptors, CCR2 Receptors, Chemokine - antagonists & inhibitors Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Rodents Signal Transduction T-Lymphocytes, Regulatory - immunology Tumor Tumors
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