Anticholinergic Risk and Frequency of Anticholinergic Drug Prescriptions in a Population Older Than 65
Abstract Objective To determine the risk and frequency of anticholinergic drug prescriptions in a population affiliated with the Colombian General System of Social Security in Health. Design A cross-sectional study was conducted in 2013. Participants Patients older than 65 years who received drugs w...
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| Veröffentlicht in: | Journal of the American Medical Directors Association 2016-03, Vol.17 (3), p.275.e1-275.e4 |
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| creator | Machado-Alba, Jorge Enrique, MD Castro-Rodríguez, Alejandro, MD Álzate-Piedrahita, John Alexander, MD Hoyos-Pulgarín, Julián Andrés, MD Medina-Morales, Diego Alejandro, MD |
| description | Abstract Objective To determine the risk and frequency of anticholinergic drug prescriptions in a population affiliated with the Colombian General System of Social Security in Health. Design A cross-sectional study was conducted in 2013. Participants Patients older than 65 years who received drugs with the potential to block cholinergic receptors, in accordance with an anticholinergic risk scale. Measurements The total anticholinergic load was determined by the sum of the risk of each prescribed drug. Results The study included a total of 27,654 patients with a mean age of 76.1 ± 7.6 years, and 61.9% were women. A total of 9.1% of the population older than 65 years had received a prescription of at least one of these drugs, and the prevalence of these prescriptions was 112.5 per 1000 members. The average number of drugs prescribed per patient was 1.4, and the drugs most frequently prescribed contained trazodone, methocarbamol, and loratadine. Being prescribed by practitioners of surgical or related specialties was the only variable significantly associated with prescriptions with high anticholinergic risk in the multivariate analysis (odds ratio 1.61; 95% confidence interval 1.335–1.934; P |
| doi_str_mv | 10.1016/j.jamda.2015.12.003 |
| format | Article |
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Design A cross-sectional study was conducted in 2013. Participants Patients older than 65 years who received drugs with the potential to block cholinergic receptors, in accordance with an anticholinergic risk scale. Measurements The total anticholinergic load was determined by the sum of the risk of each prescribed drug. Results The study included a total of 27,654 patients with a mean age of 76.1 ± 7.6 years, and 61.9% were women. A total of 9.1% of the population older than 65 years had received a prescription of at least one of these drugs, and the prevalence of these prescriptions was 112.5 per 1000 members. The average number of drugs prescribed per patient was 1.4, and the drugs most frequently prescribed contained trazodone, methocarbamol, and loratadine. Being prescribed by practitioners of surgical or related specialties was the only variable significantly associated with prescriptions with high anticholinergic risk in the multivariate analysis (odds ratio 1.61; 95% confidence interval 1.335–1.934; P < .001). Conclusion We found a high frequency of prescription medications with some degree of anticholinergic load, and in almost half of the patients, the anticholinergic risk score was very high. The prevalence of prescription of these drugs falls in the range of that reported globally. It is essential to educate prescribers about the risk to their patients.</description><identifier>ISSN: 1525-8610</identifier><identifier>EISSN: 1538-9375</identifier><identifier>DOI: 10.1016/j.jamda.2015.12.003</identifier><identifier>PMID: 26791416</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; aged 80 and older ; Aged, 80 and over ; Cholinergic antagonists ; Cholinergic Antagonists - therapeutic use ; Colombia ; Cross-Sectional Studies ; Drug Prescriptions ; Female ; health services ; Humans ; Inappropriate Prescribing ; Internal Medicine ; Male ; Medical Education ; pharmacoepidemiology (MeSH) ; Polypharmacy ; prescription drugs ; Risk Assessment</subject><ispartof>Journal of the American Medical Directors Association, 2016-03, Vol.17 (3), p.275.e1-275.e4</ispartof><rights>AMDA – The Society for Post-Acute and Long-Term Care Medicine</rights><rights>2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine</rights><rights>Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-fac6b93ff693cf68e50964ddd000a5a7c0c8fa5066d09e4e620319217eb347553</citedby><cites>FETCH-LOGICAL-c484t-fac6b93ff693cf68e50964ddd000a5a7c0c8fa5066d09e4e620319217eb347553</cites><orcidid>0000-0002-8455-0936</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1525861015007525$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26791416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machado-Alba, Jorge Enrique, MD</creatorcontrib><creatorcontrib>Castro-Rodríguez, Alejandro, MD</creatorcontrib><creatorcontrib>Álzate-Piedrahita, John Alexander, MD</creatorcontrib><creatorcontrib>Hoyos-Pulgarín, Julián Andrés, MD</creatorcontrib><creatorcontrib>Medina-Morales, Diego Alejandro, MD</creatorcontrib><title>Anticholinergic Risk and Frequency of Anticholinergic Drug Prescriptions in a Population Older Than 65</title><title>Journal of the American Medical Directors Association</title><addtitle>J Am Med Dir Assoc</addtitle><description>Abstract Objective To determine the risk and frequency of anticholinergic drug prescriptions in a population affiliated with the Colombian General System of Social Security in Health. Design A cross-sectional study was conducted in 2013. Participants Patients older than 65 years who received drugs with the potential to block cholinergic receptors, in accordance with an anticholinergic risk scale. Measurements The total anticholinergic load was determined by the sum of the risk of each prescribed drug. Results The study included a total of 27,654 patients with a mean age of 76.1 ± 7.6 years, and 61.9% were women. A total of 9.1% of the population older than 65 years had received a prescription of at least one of these drugs, and the prevalence of these prescriptions was 112.5 per 1000 members. The average number of drugs prescribed per patient was 1.4, and the drugs most frequently prescribed contained trazodone, methocarbamol, and loratadine. Being prescribed by practitioners of surgical or related specialties was the only variable significantly associated with prescriptions with high anticholinergic risk in the multivariate analysis (odds ratio 1.61; 95% confidence interval 1.335–1.934; P < .001). Conclusion We found a high frequency of prescription medications with some degree of anticholinergic load, and in almost half of the patients, the anticholinergic risk score was very high. The prevalence of prescription of these drugs falls in the range of that reported globally. It is essential to educate prescribers about the risk to their patients.</description><subject>Aged</subject><subject>aged 80 and older</subject><subject>Aged, 80 and over</subject><subject>Cholinergic antagonists</subject><subject>Cholinergic Antagonists - therapeutic use</subject><subject>Colombia</subject><subject>Cross-Sectional Studies</subject><subject>Drug Prescriptions</subject><subject>Female</subject><subject>health services</subject><subject>Humans</subject><subject>Inappropriate Prescribing</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Education</subject><subject>pharmacoepidemiology (MeSH)</subject><subject>Polypharmacy</subject><subject>prescription drugs</subject><subject>Risk Assessment</subject><issn>1525-8610</issn><issn>1538-9375</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EomXhCZCQj1wSxnHsxAeQqkIBqVIrKGfLa49bp1lnsROkfXsctnDohZNH1vd7xt8Q8ppBzYDJd0M9mJ0zdQNM1KypAfgTcsoE7yvFO_F0rRtR9ZLBCXmR8wBQUCWfk5NGdoq1TJ4SfxbnYO-mMURMt8HSbyHfUxMdvUj4c8FoD3Ty9DH1MS239Dphtins5zDFTEOkhl5P-2U06wW9Gh0menNnIpXiJXnmzZjx1cO5IT8uPt2cf6kurz5_PT-7rGzbt3PljZVbxb2XilsvexSgZOucAwAjTGfB9t4IkNKBwhZlA5yphnW45W0nBN-Qt8d392kq0-dZ70K2OI4m4rRkzTqpZNP3Jbch_IjaNOWc0Ot9CjuTDpqBXgXrQf8RrFfBmjW6CC6pNw8Nlu0O3b_MX6MFeH8EsHzzV8Cksw1FI7qQ0M7aTeE_DT48yttiPVgz3uMB8zAtKRaDmulcAvr7uuN1xUwAdKXmvwHf3aG1</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Machado-Alba, Jorge Enrique, MD</creator><creator>Castro-Rodríguez, Alejandro, MD</creator><creator>Álzate-Piedrahita, John Alexander, MD</creator><creator>Hoyos-Pulgarín, Julián Andrés, MD</creator><creator>Medina-Morales, Diego Alejandro, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8455-0936</orcidid></search><sort><creationdate>20160301</creationdate><title>Anticholinergic Risk and Frequency of Anticholinergic Drug Prescriptions in a Population Older Than 65</title><author>Machado-Alba, Jorge Enrique, MD ; Castro-Rodríguez, Alejandro, MD ; Álzate-Piedrahita, John Alexander, MD ; Hoyos-Pulgarín, Julián Andrés, MD ; Medina-Morales, Diego Alejandro, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-fac6b93ff693cf68e50964ddd000a5a7c0c8fa5066d09e4e620319217eb347553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>aged 80 and older</topic><topic>Aged, 80 and over</topic><topic>Cholinergic antagonists</topic><topic>Cholinergic Antagonists - therapeutic use</topic><topic>Colombia</topic><topic>Cross-Sectional Studies</topic><topic>Drug Prescriptions</topic><topic>Female</topic><topic>health services</topic><topic>Humans</topic><topic>Inappropriate Prescribing</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Education</topic><topic>pharmacoepidemiology (MeSH)</topic><topic>Polypharmacy</topic><topic>prescription drugs</topic><topic>Risk Assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machado-Alba, Jorge Enrique, MD</creatorcontrib><creatorcontrib>Castro-Rodríguez, Alejandro, MD</creatorcontrib><creatorcontrib>Álzate-Piedrahita, John Alexander, MD</creatorcontrib><creatorcontrib>Hoyos-Pulgarín, Julián Andrés, MD</creatorcontrib><creatorcontrib>Medina-Morales, Diego Alejandro, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Medical Directors Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machado-Alba, Jorge Enrique, MD</au><au>Castro-Rodríguez, Alejandro, MD</au><au>Álzate-Piedrahita, John Alexander, MD</au><au>Hoyos-Pulgarín, Julián Andrés, MD</au><au>Medina-Morales, Diego Alejandro, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticholinergic Risk and Frequency of Anticholinergic Drug Prescriptions in a Population Older Than 65</atitle><jtitle>Journal of the American Medical Directors Association</jtitle><addtitle>J Am Med Dir Assoc</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>17</volume><issue>3</issue><spage>275.e1</spage><epage>275.e4</epage><pages>275.e1-275.e4</pages><issn>1525-8610</issn><eissn>1538-9375</eissn><abstract>Abstract Objective To determine the risk and frequency of anticholinergic drug prescriptions in a population affiliated with the Colombian General System of Social Security in Health. Design A cross-sectional study was conducted in 2013. Participants Patients older than 65 years who received drugs with the potential to block cholinergic receptors, in accordance with an anticholinergic risk scale. Measurements The total anticholinergic load was determined by the sum of the risk of each prescribed drug. Results The study included a total of 27,654 patients with a mean age of 76.1 ± 7.6 years, and 61.9% were women. A total of 9.1% of the population older than 65 years had received a prescription of at least one of these drugs, and the prevalence of these prescriptions was 112.5 per 1000 members. The average number of drugs prescribed per patient was 1.4, and the drugs most frequently prescribed contained trazodone, methocarbamol, and loratadine. Being prescribed by practitioners of surgical or related specialties was the only variable significantly associated with prescriptions with high anticholinergic risk in the multivariate analysis (odds ratio 1.61; 95% confidence interval 1.335–1.934; P < .001). Conclusion We found a high frequency of prescription medications with some degree of anticholinergic load, and in almost half of the patients, the anticholinergic risk score was very high. The prevalence of prescription of these drugs falls in the range of that reported globally. It is essential to educate prescribers about the risk to their patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26791416</pmid><doi>10.1016/j.jamda.2015.12.003</doi><orcidid>https://orcid.org/0000-0002-8455-0936</orcidid></addata></record> |
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| subjects | Aged aged 80 and older Aged, 80 and over Cholinergic antagonists Cholinergic Antagonists - therapeutic use Colombia Cross-Sectional Studies Drug Prescriptions Female health services Humans Inappropriate Prescribing Internal Medicine Male Medical Education pharmacoepidemiology (MeSH) Polypharmacy prescription drugs Risk Assessment |
| title | Anticholinergic Risk and Frequency of Anticholinergic Drug Prescriptions in a Population Older Than 65 |
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