Selecting Patients with Ovarian Cancer for Germline BRCA Mutation Testing: Findings from Guidelines and a Systematic Literature Review

Introduction One of the most significant risk factors for the development of ovarian cancer (OC) is a genetic mutation in BRCA1 (breast cancer gene 1) or BRCA2 . Here we describe the impact of previous and current guidance on BRCA testing practices and provide evidence about which characteristics be...

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Veröffentlicht in:	Advances in therapy 2016-02, Vol.33 (2), p.129-150
Hauptverfasser:	Eccles, Diana M., Balmaña, Judith, Clune, Joe, Ehlken, Birgit, Gohlke, Annegret, Hirst, Ceri, Potter, Danielle, Schroeder, Claudia, Tyczynski, Jerzy E., Gomez Garcia, Encarnacion B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Ovarian Epithelial Cardiology Endocrinology Female Genes, BRCA1 Genes, BRCA2 Genetic Testing - standards Health technology assessment Humans Internal Medicine Medicine Medicine & Public Health Middle Aged Mutation Neoplasms, Glandular and Epithelial - genetics Oncology Ovarian Neoplasms - genetics Patient Selection Pharmacology/Toxicology Practice Guidelines as Topic Review Rheumatology Risk Factors
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