Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2

STAT5 is activated in a broad spectrum of human hematologic malignancies. We addressed whether STAT5 activation is necessary for the myelo- and lymphoproliferative disease induced by TEL/JAK2 using a genetic approach. Whereas mice transplanted with bone marrow transduced with retrovirus expressing T...

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Veröffentlicht in:	Molecular cell 2000-09, Vol.6 (3), p.693-704
Hauptverfasser:	Schwaller, Juerg, Parganas, Evan, Wang, Demin, Cain, Danielle, Aster, Jon C., Williams, Ifor R., Lee, Chien-Kuo, Gerthner, Rachel, Kitamura, Toshio, Frantsve, Julie, Anastasiadou, Ema, Loh, Mignon L., Levy, David E., Ihle, James N., Gilliland, D.Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Southern Bone Marrow Cells - pathology Bone Marrow Transplantation Colony-Forming Units Assay DNA, Neoplasm - analysis DNA-Binding Proteins - genetics Fibrosis Flow Cytometry Gene Transfer Techniques Jak2 kinase Lymphoproliferative Disorders - genetics Lymphoproliferative Disorders - physiopathology Mice Mice, Mutant Strains Milk Proteins Mutagenesis - physiology Myeloproliferative Disorders - genetics Myeloproliferative Disorders - physiopathology Neoplasm Transplantation Oncogene Proteins, Fusion - genetics Oncostatin M Peptides - genetics Phenotype Retroviridae - genetics Stat5 protein STAT5 Transcription Factor TEL protein Trans-Activators - genetics
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