Lifelong feeding of a high aluminum diet to mice
In three experiments, high aluminum diets (1000 μg Al/g diet) were fed to mice throughout their life span to determine whether neurodegenerative changes were seen with aging. Brain Al concentrations were slightly lower in Al-treated mice than controls. Generally, no increased mortality or gross evid...
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| Veröffentlicht in: | Toxicology (Amsterdam) 2000-09, Vol.150 (1), p.107-117 |
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| creator | Golub, Mari S. Germann, Stacey L. Han, Bin Keen, Carl L. |
| description | In three experiments, high aluminum diets (1000 μg Al/g diet) were fed to mice throughout their life span to determine whether neurodegenerative changes were seen with aging. Brain Al concentrations were slightly lower in Al-treated mice than controls. Generally, no increased mortality or gross evidence of neurodegeneration was seen in Al-treated mice. Eighteen and 24 month old Swiss Webster mice fed the high aluminum diet differed from controls on some neurobehavioral tests, but differences were no greater than previously seen with shorter term exposure in younger mice. Both brain Al concentration and susceptibility to oxidative damage, as measured with TBARS, were lower in the Al-treated aged mice than in controls. In addition, Al-treated aged Swiss Webster and C57BL/6J mice showed somewhat enhanced performance in the Morris water maze. Finally, Al treatment did not exacerbate the effect of MPTP treatment on a grip strength measure in either 66 or 235 day old male mice. Swiss Webster and C57BL/6J mice do not appear to provide useful models for studying Al-induced neurodegenerative changes in aging. |
| doi_str_mv | 10.1016/S0300-483X(00)00251-1 |
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Brain Al concentrations were slightly lower in Al-treated mice than controls. Generally, no increased mortality or gross evidence of neurodegeneration was seen in Al-treated mice. Eighteen and 24 month old Swiss Webster mice fed the high aluminum diet differed from controls on some neurobehavioral tests, but differences were no greater than previously seen with shorter term exposure in younger mice. Both brain Al concentration and susceptibility to oxidative damage, as measured with TBARS, were lower in the Al-treated aged mice than in controls. In addition, Al-treated aged Swiss Webster and C57BL/6J mice showed somewhat enhanced performance in the Morris water maze. Finally, Al treatment did not exacerbate the effect of MPTP treatment on a grip strength measure in either 66 or 235 day old male mice. Swiss Webster and C57BL/6J mice do not appear to provide useful models for studying Al-induced neurodegenerative changes in aging.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/S0300-483X(00)00251-1</identifier><identifier>PMID: 10996667</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aging mice ; Aluminum ; Aluminum - toxicity ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Body Temperature - drug effects ; Body Weight - drug effects ; Brain - drug effects ; Brain behavior ; Chemical and industrial products toxicology. Toxic occupational diseases ; Eating - drug effects ; Female ; Iron manganese ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Male ; Maze Learning - drug effects ; Medical sciences ; Metals and various inorganic compounds ; Mice ; Mice, Inbred C57BL ; MPTP ; MPTP Poisoning - psychology ; Sex Factors ; Toxicology</subject><ispartof>Toxicology (Amsterdam), 2000-09, Vol.150 (1), p.107-117</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-2024a968fa7aa142d5b2ead73c0e70ef23c322505bb7c6d8f412d3e4448762893</citedby><cites>FETCH-LOGICAL-c452t-2024a968fa7aa142d5b2ead73c0e70ef23c322505bb7c6d8f412d3e4448762893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0300-483X(00)00251-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1512676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10996667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Golub, Mari S.</creatorcontrib><creatorcontrib>Germann, Stacey L.</creatorcontrib><creatorcontrib>Han, Bin</creatorcontrib><creatorcontrib>Keen, Carl L.</creatorcontrib><title>Lifelong feeding of a high aluminum diet to mice</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>In three experiments, high aluminum diets (1000 μg Al/g diet) were fed to mice throughout their life span to determine whether neurodegenerative changes were seen with aging. Brain Al concentrations were slightly lower in Al-treated mice than controls. Generally, no increased mortality or gross evidence of neurodegeneration was seen in Al-treated mice. Eighteen and 24 month old Swiss Webster mice fed the high aluminum diet differed from controls on some neurobehavioral tests, but differences were no greater than previously seen with shorter term exposure in younger mice. Both brain Al concentration and susceptibility to oxidative damage, as measured with TBARS, were lower in the Al-treated aged mice than in controls. In addition, Al-treated aged Swiss Webster and C57BL/6J mice showed somewhat enhanced performance in the Morris water maze. Finally, Al treatment did not exacerbate the effect of MPTP treatment on a grip strength measure in either 66 or 235 day old male mice. Swiss Webster and C57BL/6J mice do not appear to provide useful models for studying Al-induced neurodegenerative changes in aging.</description><subject>Aging mice</subject><subject>Aluminum</subject><subject>Aluminum - toxicity</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Brain - drug effects</subject><subject>Brain behavior</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Eating - drug effects</subject><subject>Female</subject><subject>Iron manganese</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>MPTP</subject><subject>MPTP Poisoning - psychology</subject><subject>Sex Factors</subject><subject>Toxicology</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MlKxTAUgOEgil6HR1C6ENFF9WRuVyLiBBdcqOAu5KYnGumgTSv49uYOqDtXZ_OdDD8h-xROKVB19gAcIBcFfz4GOAFgkuZ0jUxoocuc00Kuk8kP2SLbMb5BUlyoTbJFoSyVUnpCYBo81l37knnEKqTZ-cxmr-HlNbP12IR2bLIq4JANXdYEh7tkw9s64t5q7pCn66vHy9t8en9zd3kxzZ2QbMgZMGFLVXirraWCVXLG0FaaO0AN6Bl3nDEJcjbTTlWFF5RVHIUQhVasKPkOOVqe-953HyPGwTQhOqxr22I3RkO1KqlQ4n8opCjSxxOUS-j6LsYevXnvQ2P7L0PBzJuaRVMzD2bSXDQ1NO0drC4YZw1Wf7aWERM4XAEbna19b1sX4q-TlCmtEjtfMkzZPgP2JrqArUvZe3SDqbrwz0u-AcBIkF8</recordid><startdate>20000907</startdate><enddate>20000907</enddate><creator>Golub, Mari S.</creator><creator>Germann, Stacey L.</creator><creator>Han, Bin</creator><creator>Keen, Carl L.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope></search><sort><creationdate>20000907</creationdate><title>Lifelong feeding of a high aluminum diet to mice</title><author>Golub, Mari S. ; Germann, Stacey L. ; Han, Bin ; Keen, Carl L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-2024a968fa7aa142d5b2ead73c0e70ef23c322505bb7c6d8f412d3e4448762893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aging mice</topic><topic>Aluminum</topic><topic>Aluminum - toxicity</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Brain - drug effects</topic><topic>Brain behavior</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Eating - drug effects</topic><topic>Female</topic><topic>Iron manganese</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>MPTP</topic><topic>MPTP Poisoning - psychology</topic><topic>Sex Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Golub, Mari S.</creatorcontrib><creatorcontrib>Germann, Stacey L.</creatorcontrib><creatorcontrib>Han, Bin</creatorcontrib><creatorcontrib>Keen, Carl L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golub, Mari S.</au><au>Germann, Stacey L.</au><au>Han, Bin</au><au>Keen, Carl L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lifelong feeding of a high aluminum diet to mice</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2000-09-07</date><risdate>2000</risdate><volume>150</volume><issue>1</issue><spage>107</spage><epage>117</epage><pages>107-117</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>In three experiments, high aluminum diets (1000 μg Al/g diet) were fed to mice throughout their life span to determine whether neurodegenerative changes were seen with aging. Brain Al concentrations were slightly lower in Al-treated mice than controls. Generally, no increased mortality or gross evidence of neurodegeneration was seen in Al-treated mice. Eighteen and 24 month old Swiss Webster mice fed the high aluminum diet differed from controls on some neurobehavioral tests, but differences were no greater than previously seen with shorter term exposure in younger mice. Both brain Al concentration and susceptibility to oxidative damage, as measured with TBARS, were lower in the Al-treated aged mice than in controls. In addition, Al-treated aged Swiss Webster and C57BL/6J mice showed somewhat enhanced performance in the Morris water maze. Finally, Al treatment did not exacerbate the effect of MPTP treatment on a grip strength measure in either 66 or 235 day old male mice. 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| subjects | Aging mice Aluminum Aluminum - toxicity Animals Behavior, Animal - drug effects Biological and medical sciences Body Temperature - drug effects Body Weight - drug effects Brain - drug effects Brain behavior Chemical and industrial products toxicology. Toxic occupational diseases Eating - drug effects Female Iron manganese Lipid peroxidation Lipid Peroxidation - drug effects Male Maze Learning - drug effects Medical sciences Metals and various inorganic compounds Mice Mice, Inbred C57BL MPTP MPTP Poisoning - psychology Sex Factors Toxicology |
| title | Lifelong feeding of a high aluminum diet to mice |
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