Bleomycin-induced pulmonary fibrosis is independent of eosinophils

Eosinophils have been shown to increase in tissues during many fibrotic conditions and consequently have been suggested to contribute to the development of fibrosis. This study tested the hypothesis that eosinophils are essential in the development of lung fibrosis in mice in response to bleomycin (...

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Veröffentlicht in:	Journal of leukocyte biology 2000-10, Vol.68 (4), p.515-521
Hauptverfasser:	Hao, Huiqing, Cohen, Donald A., Jennings, C. Darrell, Bryson, J. Scott, Kaplan, Alan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use bleomycin Bleomycin - toxicity Collagen - analysis cytokines Eosinophil Peroxidase Eosinophils - physiology Gene Expression Regulation - drug effects hydroxyproline Hydroxyproline - analysis Interleukin-5 - antagonists & inhibitors Interleukin-5 - deficiency Interleukin-5 - genetics Interleukin-5 - immunology Interleukin-6 - biosynthesis Interleukin-6 - genetics knockout mice Lung - chemistry Lung - metabolism Lung - pathology lung eosinophilia Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout Mice, SCID Peroxidases - analysis Pulmonary Eosinophilia - chemically induced Pulmonary Eosinophilia - complications Pulmonary Eosinophilia - physiopathology Pulmonary Eosinophilia - prevention & control Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - complications Pulmonary Fibrosis - physiopathology RNA, Messenger - biosynthesis RNA, Messenger - genetics Specific Pathogen-Free Organisms Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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