Molecular mechanisms regulating the retrograde axonal transport of neurotrophins
Neurotrophins are released from target tissues following neural innervation and bind to specific receptors situated on the nerve terminal plasma membrane. The neurotrophin-receptor complex undergoes retrograde axonal transport towards the cell soma, where it signals to the nucleus. This process allo...
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| Veröffentlicht in: | Brain Research Reviews 2000-09, Vol.33 (2), p.169-178 |
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| creator | Reynolds, Anna J Bartlett, Selena E Hendry, Ian A |
| description | Neurotrophins are released from target tissues following neural innervation and bind to specific receptors situated on the nerve terminal plasma membrane. The neurotrophin-receptor complex undergoes retrograde axonal transport towards the cell soma, where it signals to the nucleus. This process allows neurotrophins to perform their numerous functions, which include the promotion of neuronal survival and the outgrowth of axons towards certain target tissues. The molecular events controlling each of the components of retrograde axonal transport are beginning to become defined. There is good evidence for the participation of phosphatidylinositol 3-kinase, phosphatidylinositol 4-kinase and the actin cytoskeleton in neurotrophin retrograde axonal transport in vivo. It also appears that the retrograde motor protein dynein mediates the retrograde axonal transport in vivo of neurotrophins such as nerve growth factor. This review discusses the role of the neurotrophin receptors in binding and axonal transport, the endocytic processes required for neurotrophin internalization, the targeting and trafficking of neurotrophins, and the propagation of neurotrophin-induced signals along the axon. |
| doi_str_mv | 10.1016/S0165-0173(00)00028-X |
| format | Article |
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The neurotrophin-receptor complex undergoes retrograde axonal transport towards the cell soma, where it signals to the nucleus. This process allows neurotrophins to perform their numerous functions, which include the promotion of neuronal survival and the outgrowth of axons towards certain target tissues. The molecular events controlling each of the components of retrograde axonal transport are beginning to become defined. There is good evidence for the participation of phosphatidylinositol 3-kinase, phosphatidylinositol 4-kinase and the actin cytoskeleton in neurotrophin retrograde axonal transport in vivo. It also appears that the retrograde motor protein dynein mediates the retrograde axonal transport in vivo of neurotrophins such as nerve growth factor. 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Psychology</subject><subject>Humans</subject><subject>Membrane and intracellular transports</subject><subject>Molecular and cellular biology</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Neurotrophic factor</subject><subject>phosphatidylinositol 4-kinase</subject><subject>Receptor Protein-Tyrosine Kinases - metabolism</subject><subject>Retrograde axonal transport</subject><subject>Sensory neuron</subject><subject>Signal transduction</subject><subject>Sympathetic neuron</subject><issn>0165-0173</issn><issn>1872-6321</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMobk5_glIQRC-q-ejS9Epk-AUTBRV2F9L0dIu0zUxa0X9vtpV56U2SE57znsOD0DHBlwQTfvUajnGMScrOMb7AGFMRz3bQkIiUxpxRsouGW2SADrz_wHicJYLvowEJEQTzZIhenmwFuquUi2rQC9UYX_vIwTx8taaZR-0CQtk6O3eqgEh920ZVUetU45fWtZEtowY6ZwOxXJjGH6K9UlUejvp7hN7vbt8mD_H0-f5xcjONNRNZG4skL5KU6TTJgZVZmeakCCuNhaYqI2Ua3lSJnCdc5yopKBOJYJxQKnhR8oyzETrb5C6d_ezAt7I2XkNVqQZs5yVJueCM4QCON6B21nsHpVw6Uyv3IwmWK5VyrVKuPEmM5VqlnIW-k35Al9dQ_HX17gJw2gPKa1WVQYk2fssJTAllgbreUBBkfBlw0msDjYbCONCtLKz5Z5FfbGuQUA</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Reynolds, Anna J</creator><creator>Bartlett, Selena E</creator><creator>Hendry, Ian A</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20000901</creationdate><title>Molecular mechanisms regulating the retrograde axonal transport of neurotrophins</title><author>Reynolds, Anna J ; Bartlett, Selena E ; Hendry, Ian A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-84bd473c74be3f9f7b1d11058c2a91f71102a8b646cba4d238483612286df6963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Axonal Transport - physiology</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Membrane and intracellular transports</topic><topic>Molecular and cellular biology</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Neurotrophic factor</topic><topic>phosphatidylinositol 4-kinase</topic><topic>Receptor Protein-Tyrosine Kinases - metabolism</topic><topic>Retrograde axonal transport</topic><topic>Sensory neuron</topic><topic>Signal transduction</topic><topic>Sympathetic neuron</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reynolds, Anna J</creatorcontrib><creatorcontrib>Bartlett, Selena E</creatorcontrib><creatorcontrib>Hendry, Ian A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain Research Reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reynolds, Anna J</au><au>Bartlett, Selena E</au><au>Hendry, Ian A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular mechanisms regulating the retrograde axonal transport of neurotrophins</atitle><jtitle>Brain Research Reviews</jtitle><addtitle>Brain Res Brain Res Rev</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>33</volume><issue>2</issue><spage>169</spage><epage>178</epage><pages>169-178</pages><issn>0165-0173</issn><eissn>1872-6321</eissn><abstract>Neurotrophins are released from target tissues following neural innervation and bind to specific receptors situated on the nerve terminal plasma membrane. The neurotrophin-receptor complex undergoes retrograde axonal transport towards the cell soma, where it signals to the nucleus. This process allows neurotrophins to perform their numerous functions, which include the promotion of neuronal survival and the outgrowth of axons towards certain target tissues. The molecular events controlling each of the components of retrograde axonal transport are beginning to become defined. There is good evidence for the participation of phosphatidylinositol 3-kinase, phosphatidylinositol 4-kinase and the actin cytoskeleton in neurotrophin retrograde axonal transport in vivo. It also appears that the retrograde motor protein dynein mediates the retrograde axonal transport in vivo of neurotrophins such as nerve growth factor. 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| ispartof | Brain Research Reviews, 2000-09, Vol.33 (2), p.169-178 |
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| language | eng |
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| subjects | Animals Axonal Transport - physiology Biological and medical sciences Cell physiology Fundamental and applied biological sciences. Psychology Humans Membrane and intracellular transports Molecular and cellular biology Nerve Growth Factors - metabolism Neurotrophic factor phosphatidylinositol 4-kinase Receptor Protein-Tyrosine Kinases - metabolism Retrograde axonal transport Sensory neuron Signal transduction Sympathetic neuron |
| title | Molecular mechanisms regulating the retrograde axonal transport of neurotrophins |
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