Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine

Currently, the low efficacy of antinociceptive drugs for the treatment of neuropathic pain is a major therapeutic problem. Here, we show the potential role of interleukin (IL)-18 signaling in this phenomenon. IL-18 is an important molecule that performs various crucial functions, including the alter...

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Veröffentlicht in:	Molecular and cellular neuroscience 2016-03, Vol.71, p.114-124
Hauptverfasser:	Pilat, Dominika, Piotrowska, Anna, Rojewska, Ewelina, Jurga, Agnieszka, Ślusarczyk, Joanna, Makuch, Wioletta, Basta-Kaim, Agnieszka, Przewlocka, Barbara, Mika, Joanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Analgesics, Opioid - therapeutic use Animals Astrocytes - drug effects Astrocytes - metabolism Buprenorphine - administration & dosage Buprenorphine - pharmacology Buprenorphine - therapeutic use Cells, Cultured Drug Synergism IL-18 IL-18BP IL-18R Intercellular Signaling Peptides and Proteins - administration & dosage Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - pharmacology Interleukin-18 - genetics Interleukin-18 - metabolism Male Morphine - administration & dosage Morphine - pharmacology Morphine - therapeutic use Neuralgia - drug therapy Neuralgia - metabolism Neurons - drug effects Neurons - metabolism Neuropathic pain Opioid treatment Rats Rats, Wistar Receptors, Interleukin-18 - genetics Receptors, Interleukin-18 - metabolism Spinal Cord - cytology Spinal Cord - metabolism
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