Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide

Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide

Polyethylene glycol (PEG) of different lengths was genetically incorporated into the backbone of a polypeptide using stop-anticodon and frameshift anticodon-containing tRNAs, which were acylated with PEG-containing amino acids.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-10, Vol.51 (76), p.14385-14388
Hauptverfasser: Zang, Qingmin, Tada, Seiichi, Uzawa, Takanori, Kiga, Daisuke, Yamamura, Masayuki, Ito, Yoshihiro
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Amino Acid Sequence
Amino acids
Amino Acids - chemistry
Amino Acids - genetics
Anticodon
Backbone
Genetics
Molecular Sequence Data
Peptides
Peptides - chemistry
Peptides - genetics
Polyethylene glycol
Polyethylene Glycols - chemistry
Polypeptides
Protein Biosynthesis
RNA, Transfer - chemistry
RNA, Transfer - genetics
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Beschreibung
Zusammenfassung:Polyethylene glycol (PEG) of different lengths was genetically incorporated into the backbone of a polypeptide using stop-anticodon and frameshift anticodon-containing tRNAs, which were acylated with PEG-containing amino acids.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc04486c