Improved Specificity of Gene Electrotransfer to Skin Using pDNA Under the Control of Collagen Tissue-Specific Promoter

In order to ensure safe, efficient and controlled gene delivery to skin, the improvement of delivery methods together with proper design of DNA is required. Non-viral delivery methods, such as gene electrotransfer, and the design of tissue-specific promoters are promising tools to ensure the safety...

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Veröffentlicht in:	The Journal of membrane biology 2015-10, Vol.248 (5), p.919-928
Hauptverfasser:	Kos, Spela, Tesic, Natasa, Kamensek, Urska, Blagus, Tanja, Cemazar, Maja, Kranjc, Simona, Lavrencak, Jaka, Sersa, Gregor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Cell Survival Cells, Cultured Collagen Collagen - metabolism DNA - metabolism Electric fields Electroporation - methods Endothelial Cells - metabolism Female Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Gene Transfer Techniques Genes Genes, Reporter - genetics Genetic Therapy - methods Human Physiology Interleukin-12 - administration & dosage Interleukin-12 - metabolism Life Sciences Mice Mice, Inbred BALB C Organ Specificity Plasmids - administration & dosage Plasmids - genetics Promoter Regions, Genetic - genetics Skin Skin - metabolism Tissues Transfection - methods
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