Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid

Sun and colleagues show that the deubiquitinase Trabid mediates the TLR-induced deubiqutination and stabilization of the histone demethylase Jmjd2d at the Il12 and Il23 promoters in dendritic cells. The proinflammatory cytokines interleukin 12 (IL-12) and IL-23 connect innate responses and adaptive...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2016-03, Vol.17 (3), p.259-268
Hauptverfasser:	Jin, Jin, Xie, Xiaoping, Xiao, Yichuan, Hu, Hongbo, Zou, Qiang, Cheng, Xuhong, Sun, Shao-Cong
Format:	Artikel
Sprache:	eng
Schlagworte:	38/109 42/41 42/89 45/15 631/250/2502/2170 631/250/38 631/250/516 96/31 96/95 Animals Biomedicine CD4-Positive T-Lymphocytes - immunology Cell Differentiation Chromatin Immunoprecipitation Dendritic Cells - immunology Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Epigenesis, Genetic Flow Cytometry Gene Expression Regulation Gene Knockdown Techniques Immunoblotting Immunology Immunoprecipitation Infectious Diseases Interleukin-12 - genetics Interleukin-12 - immunology Interleukin-23 - genetics Interleukin-23 - immunology Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Mice Reverse Transcriptase Polymerase Chain Reaction RNA-Binding Proteins - genetics RNA-Binding Proteins - immunology Signal Transduction Toll-Like Receptors - metabolism Ubiquitin-Specific Proteases - genetics Ubiquitin-Specific Proteases - immunology Zinc Fingers - genetics Zinc Fingers - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!