Angiotensin-converting Enzyme Inhibitor-induced Angioedema and Hereditary Angioedema: A Comparison Study of Attack Severity
Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospec...
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| Veröffentlicht in: | Internal Medicine 2015, Vol.54(20), pp.2583-2588 |
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| creator | Javaud, Nicolas Charpentier, Stéphane Lapostolle, Frédéric Lekouara, Hakim Boubaya, Marouane Lenoir, Gilles Mekinian, Arsène Adnet, Frédéric Fain, Olivier |
| description | Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE. The attack characteristics experienced by the patients were compared by a logistic regression analysis using generalized estimating equations. Results A total of 56 patients were included in this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. Severe attacks were more common in the patients who had an acute episode of ACE-I AE than HAE. Swelling of the tongue, lips and larynx were significantly associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling of the tongue, lips and larynx are significantly more frequent in drug-induced AE than HAE. |
| doi_str_mv | 10.2169/internalmedicine.54.4181 |
| format | Article |
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The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE. The attack characteristics experienced by the patients were compared by a logistic regression analysis using generalized estimating equations. Results A total of 56 patients were included in this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. Severe attacks were more common in the patients who had an acute episode of ACE-I AE than HAE. Swelling of the tongue, lips and larynx were significantly associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling of the tongue, lips and larynx are significantly more frequent in drug-induced AE than HAE.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.54.4181</identifier><identifier>PMID: 26466692</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>ACE-I AE ; Adult ; Aged ; Aged, 80 and over ; Angioedema - chemically induced ; Angioedema - diagnosis ; Angioedema - pathology ; Angioedemas, Hereditary - diagnosis ; Angioedemas, Hereditary - pathology ; Angiotensin-Converting Enzyme Inhibitors - administration & dosage ; Angiotensin-Converting Enzyme Inhibitors - adverse effects ; bradykinin ; emergency ; Female ; hereditary angioedema ; Humans ; Immunosuppressive Agents - adverse effects ; Larynx - drug effects ; Larynx - pathology ; Lip - drug effects ; Lip - pathology ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Tongue - drug effects ; Tongue - pathology ; Young Adult</subject><ispartof>Internal Medicine, 2015, Vol.54(20), pp.2583-2588</ispartof><rights>2015 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-e7d1148ab090f6d641831e11a67ceff0d2bc5a57ae42ebab796d7e03130a14893</citedby><cites>FETCH-LOGICAL-c617t-e7d1148ab090f6d641831e11a67ceff0d2bc5a57ae42ebab796d7e03130a14893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26466692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Javaud, Nicolas</creatorcontrib><creatorcontrib>Charpentier, Stéphane</creatorcontrib><creatorcontrib>Lapostolle, Frédéric</creatorcontrib><creatorcontrib>Lekouara, Hakim</creatorcontrib><creatorcontrib>Boubaya, Marouane</creatorcontrib><creatorcontrib>Lenoir, Gilles</creatorcontrib><creatorcontrib>Mekinian, Arsène</creatorcontrib><creatorcontrib>Adnet, Frédéric</creatorcontrib><creatorcontrib>Fain, Olivier</creatorcontrib><title>Angiotensin-converting Enzyme Inhibitor-induced Angioedema and Hereditary Angioedema: A Comparison Study of Attack Severity</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE. The attack characteristics experienced by the patients were compared by a logistic regression analysis using generalized estimating equations. Results A total of 56 patients were included in this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. Severe attacks were more common in the patients who had an acute episode of ACE-I AE than HAE. Swelling of the tongue, lips and larynx were significantly associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling of the tongue, lips and larynx are significantly more frequent in drug-induced AE than HAE.</description><subject>ACE-I AE</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioedema - chemically induced</subject><subject>Angioedema - diagnosis</subject><subject>Angioedema - pathology</subject><subject>Angioedemas, Hereditary - diagnosis</subject><subject>Angioedemas, Hereditary - pathology</subject><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</subject><subject>Angiotensin-Converting Enzyme Inhibitors - adverse effects</subject><subject>bradykinin</subject><subject>emergency</subject><subject>Female</subject><subject>hereditary angioedema</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Larynx - drug effects</subject><subject>Larynx - pathology</subject><subject>Lip - drug effects</subject><subject>Lip - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Tongue - drug effects</subject><subject>Tongue - pathology</subject><subject>Young Adult</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9vEzEQxS1ERUPbr4B85LLBf3ZtL7coKrRSpR5KzyuvPZu67NrB9iKlfHkcEiKEOHCZOczvzbPnIYQpWTIq2g_OZ4hejxNYZ5yHZVMva6roK7SgvG4ryXjzGi1IS1XFSjlHb1N6JoQr2bI36JyJWgjRsgX6sfIbFzL45Hxlgv8OMTu_wdf-ZTcBvvVPrnc5xMp5Oxuw-BcPFiaNtbf4BmJ5Q9Zx98fkI17hdZi2OroUPH7Is93hMOBVztp8xQ9QXFzeXaKzQY8Jro79Aj1-uv6yvqnu7j_frld3lRFU5gqkpbRWuictGYQV5aOcAqVaSAPDQCzrTaMbqaFm0OtetsJKIJxyoouu5Rfo_WHvNoZvM6TcTS4ZGEftIcypo1KoRjWU8f9AGWs5lUoVVB1QE0NKEYZuG91UDtFR0u1T6v5OqWvqbp9Skb47usx9GZ6Ev2MpwP0BeE5Zb-AE6BKOGeGfmxnZ16PFiTRPOnbg-U9OaLJj</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Javaud, Nicolas</creator><creator>Charpentier, Stéphane</creator><creator>Lapostolle, Frédéric</creator><creator>Lekouara, Hakim</creator><creator>Boubaya, Marouane</creator><creator>Lenoir, Gilles</creator><creator>Mekinian, Arsène</creator><creator>Adnet, Frédéric</creator><creator>Fain, Olivier</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20150101</creationdate><title>Angiotensin-converting Enzyme Inhibitor-induced Angioedema and Hereditary Angioedema: A Comparison Study of Attack Severity</title><author>Javaud, Nicolas ; Charpentier, Stéphane ; Lapostolle, Frédéric ; Lekouara, Hakim ; Boubaya, Marouane ; Lenoir, Gilles ; Mekinian, Arsène ; Adnet, Frédéric ; Fain, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c617t-e7d1148ab090f6d641831e11a67ceff0d2bc5a57ae42ebab796d7e03130a14893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>ACE-I AE</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angioedema - chemically induced</topic><topic>Angioedema - diagnosis</topic><topic>Angioedema - pathology</topic><topic>Angioedemas, Hereditary - diagnosis</topic><topic>Angioedemas, Hereditary - pathology</topic><topic>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</topic><topic>Angiotensin-Converting Enzyme Inhibitors - adverse effects</topic><topic>bradykinin</topic><topic>emergency</topic><topic>Female</topic><topic>hereditary angioedema</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Larynx - drug effects</topic><topic>Larynx - pathology</topic><topic>Lip - drug effects</topic><topic>Lip - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Tongue - drug effects</topic><topic>Tongue - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Javaud, Nicolas</creatorcontrib><creatorcontrib>Charpentier, Stéphane</creatorcontrib><creatorcontrib>Lapostolle, Frédéric</creatorcontrib><creatorcontrib>Lekouara, Hakim</creatorcontrib><creatorcontrib>Boubaya, Marouane</creatorcontrib><creatorcontrib>Lenoir, Gilles</creatorcontrib><creatorcontrib>Mekinian, Arsène</creatorcontrib><creatorcontrib>Adnet, Frédéric</creatorcontrib><creatorcontrib>Fain, Olivier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Javaud, Nicolas</au><au>Charpentier, Stéphane</au><au>Lapostolle, Frédéric</au><au>Lekouara, Hakim</au><au>Boubaya, Marouane</au><au>Lenoir, Gilles</au><au>Mekinian, Arsène</au><au>Adnet, Frédéric</au><au>Fain, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin-converting Enzyme Inhibitor-induced Angioedema and Hereditary Angioedema: A Comparison Study of Attack Severity</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>54</volume><issue>20</issue><spage>2583</spage><epage>2588</epage><pages>2583-2588</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE. The attack characteristics experienced by the patients were compared by a logistic regression analysis using generalized estimating equations. Results A total of 56 patients were included in this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. Severe attacks were more common in the patients who had an acute episode of ACE-I AE than HAE. Swelling of the tongue, lips and larynx were significantly associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling of the tongue, lips and larynx are significantly more frequent in drug-induced AE than HAE.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>26466692</pmid><doi>10.2169/internalmedicine.54.4181</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ACE-I AE Adult Aged Aged, 80 and over Angioedema - chemically induced Angioedema - diagnosis Angioedema - pathology Angioedemas, Hereditary - diagnosis Angioedemas, Hereditary - pathology Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - adverse effects bradykinin emergency Female hereditary angioedema Humans Immunosuppressive Agents - adverse effects Larynx - drug effects Larynx - pathology Lip - drug effects Lip - pathology Male Middle Aged Retrospective Studies Severity of Illness Index Tongue - drug effects Tongue - pathology Young Adult |
| title | Angiotensin-converting Enzyme Inhibitor-induced Angioedema and Hereditary Angioedema: A Comparison Study of Attack Severity |
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