Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults

Abstract Overweight/obesity is associated with chronic inflammation and impairs both innate and adaptive immune responses. Limonoids found in citrus fruits decreased cell proliferation and inflammation in animal studies. We hypothesized that limonin glucoside (LG) supplementation in vivo will decrea...

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Veröffentlicht in:	Nutrition research (New York, N.Y.) N.Y.), 2016-01, Vol.36 (1), p.24-30
Hauptverfasser:	Zunino, Susan J, Storms, David H, Freytag, Tammy L, Adkins, Yuriko C, Bonnel, Ellen L, Woodhouse, Leslie R, Breksa, Andrew P, Manners, Gary D, Mackey, Bruce E, Kelley, Darshan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Beverages - adverse effects Biomarkers - blood Biomarkers - metabolism Body Mass Index Cell Proliferation Cells, Cultured Citrus Citrus - chemistry Citrus limonin glucoside Cross-Over Studies Cytokines Dietary Supplements - adverse effects Double-Blind Method Female Fruit - chemistry Gastroenterology and Hepatology Glucosides - adverse effects Glucosides - metabolism Glucosides - therapeutic use Hepatitis - etiology Hepatitis - prevention & control Humans Limonins - adverse effects Limonins - metabolism Limonins - therapeutic use Male Metabolic Syndrome - etiology Metabolic Syndrome - prevention & control Middle Aged Monocytes Monocytes - immunology Monocytes - metabolism Monocytes - pathology Obesity - diet therapy Obesity - immunology Obesity - metabolism Obesity - pathology Overweight - diet therapy Overweight - immunology Overweight - metabolism Overweight - pathology Overweight/obese humans T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology
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