Effect of Brain-Derived Neurotrophic Factor on Mesenchymal Stem Cell-Seeded Electrospinning Biomaterial for Treating Ischemic Diabetic Ulcers via Milieu-Dependent Differentiation Mechanism

Great challenges in transplantation of mesenchymal stem cells (MSCs) for treating ischemic diabetic ulcers (IDUs) are to find a suitable carrier and create a beneficial microenvironment. Brain-derived neurotrophic factor (BDNF), a member of neurotrophin family, is considered angiogenic and neuroprot...

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Veröffentlicht in:	Tissue engineering. Part A 2015-03, Vol.21 (5-6), p.928-938
Hauptverfasser:	He, Siyi, Shen, Lei, Wu, Yangxiao, Li, Li, Chen, Wen, Hou, Chunli, Yang, Mingcan, Zeng, Wen, Zhu, Chuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - pharmacology Biocompatible Materials - therapeutic use Biomedical materials Brain Brain-Derived Neurotrophic Factor - pharmacology Brain-Derived Neurotrophic Factor - therapeutic use Cell Differentiation - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Cellular Microenvironment - drug effects Collagen - pharmacology Culture Media, Conditioned - pharmacology Cytokines - metabolism Diabetic Foot - drug therapy Diabetic Foot - pathology Diabetic Foot - physiopathology Hindlimb - blood supply Hindlimb - pathology Human Umbilical Vein Endothelial Cells Humans Ischemia Ischemia - drug therapy Ischemia - pathology Ischemia - physiopathology Male Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mice, Inbred C57BL Neovascularization, Physiologic - drug effects Original Articles Stem cells Wound healing Wound Healing - drug effects
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