biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects
FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerat...
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| Veröffentlicht in: | Journal of industrial microbiology & biotechnology 2016-03, Vol.43 (2-3), p.389-400 |
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| container_title | Journal of industrial microbiology & biotechnology |
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| creator | Ban, Yeon Hee Park, Sung Ryeol Yoon, Yeo Joon |
| description | FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized. |
| doi_str_mv | 10.1007/s10295-015-1677-7 |
| format | Article |
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In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. 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In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized.</description><subject>Animals</subject><subject>bioactive properties</subject><subject>biochemical pathways</subject><subject>Biochemistry</subject><subject>Bioinformatics</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Biosynthetic Pathways - genetics</subject><subject>Biotechnology</subject><subject>Cytokines</subject><subject>engineering</subject><subject>Genes</subject><subject>Genetic Engineering</subject><subject>Genetics and Molecular Biology of Industrial Organisms</subject><subject>Immunosuppressive Agents - metabolism</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Inorganic Chemistry</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>macrolides</subject><subject>mechanism of action</subject><subject>Metabolic Engineering - trends</subject><subject>Microbiology</subject><subject>Natural products</subject><subject>Pharmaceutical industry</subject><subject>Phosphatase</subject><subject>Streptomyces</subject><subject>Streptomyces - classification</subject><subject>Streptomyces - genetics</subject><subject>Streptomyces - metabolism</subject><subject>Studies</subject><subject>Tacrolimus - analogs & derivatives</subject><subject>Tacrolimus - metabolism</subject><subject>Tacrolimus - pharmacology</subject><subject>Toxicity</subject><issn>1367-5435</issn><issn>1476-5535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU2LFDEQhoMo7of-AC8a8LKX1krSSXW8LYur4oIH3aOETLp6ppfpD5O0Mv_eDL2KeBBPyeF536LqYeyZgFcCAF8nAdLqCoSuhEGs8AE7FTWaSmulH5a_MljpWukTdpbSHQBoRPmYnUijaqmEPWVfN_2UDmPeUe4Dn33e_fAHPnX8-qMGw_3Y8j4nTuO2H4liP27f8C5OQ0FT5j7sevpOA42FyRPvlrxE4nOc0kwhpyfsUef3iZ7ev-fs9vrtl6v31c2ndx-uLm-qoNHmCkNLxjTG2mDagB1SYxuUjdj4RteooQuwwUDeBt3WqhVgpCpQCAGpVa06Zxdrb5n8baGU3dCnQPu9H2lakhNoGo0NaPU_qBZCKikK-vIv9G5a4lgWOVJ1o1QNtlBipULZOkXq3Bz7wceDE-COmtyqyRVN7qjJYck8v29eNgO1vxO_vBRArkCajzen-Mfof7S-WEOdn5zfxj65288ShAEQAmrbqJ-vMqWz</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Ban, Yeon Hee</creator><creator>Park, Sung Ryeol</creator><creator>Yoon, Yeo Joon</creator><general>Springer Berlin Heidelberg</general><general>Oxford University Press</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20160301</creationdate><title>biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects</title><author>Ban, Yeon Hee ; Park, Sung Ryeol ; Yoon, Yeo Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-7cde668699c6dc7f7e8987281ba854750fc0b7cea9c5d43d106237e8ccc7ed3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>bioactive properties</topic><topic>biochemical pathways</topic><topic>Biochemistry</topic><topic>Bioinformatics</topic><topic>Biological activity</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Biosynthetic Pathways - genetics</topic><topic>Biotechnology</topic><topic>Cytokines</topic><topic>engineering</topic><topic>Genes</topic><topic>Genetic Engineering</topic><topic>Genetics and Molecular Biology of Industrial Organisms</topic><topic>Immunosuppressive Agents - metabolism</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Inorganic Chemistry</topic><topic>Life Sciences</topic><topic>Lymphocytes</topic><topic>macrolides</topic><topic>mechanism of action</topic><topic>Metabolic Engineering - trends</topic><topic>Microbiology</topic><topic>Natural products</topic><topic>Pharmaceutical industry</topic><topic>Phosphatase</topic><topic>Streptomyces</topic><topic>Streptomyces - classification</topic><topic>Streptomyces - genetics</topic><topic>Streptomyces - metabolism</topic><topic>Studies</topic><topic>Tacrolimus - analogs & derivatives</topic><topic>Tacrolimus - metabolism</topic><topic>Tacrolimus - pharmacology</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ban, Yeon Hee</creatorcontrib><creatorcontrib>Park, Sung Ryeol</creatorcontrib><creatorcontrib>Yoon, Yeo Joon</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ProQuest Biological Science Collection</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database (ProQuest)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26342319</pmid><doi>10.1007/s10295-015-1677-7</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals bioactive properties biochemical pathways Biochemistry Bioinformatics Biological activity Biomedical and Life Sciences Biosynthesis Biosynthetic Pathways - genetics Biotechnology Cytokines engineering Genes Genetic Engineering Genetics and Molecular Biology of Industrial Organisms Immunosuppressive Agents - metabolism Immunosuppressive Agents - pharmacology Inorganic Chemistry Life Sciences Lymphocytes macrolides mechanism of action Metabolic Engineering - trends Microbiology Natural products Pharmaceutical industry Phosphatase Streptomyces Streptomyces - classification Streptomyces - genetics Streptomyces - metabolism Studies Tacrolimus - analogs & derivatives Tacrolimus - metabolism Tacrolimus - pharmacology Toxicity |
| title | biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects |
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