MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment

Abstract Multiple sclerosis associated retrovirus envelope protein (MSRV-Env) was repeatedly detected in brain lesions and blood of multiple sclerosis (MS) patients. We performed the first pharmacological characterisation of MSRV-Env on recombinant and native human TLR4. MSRV-Env is a full and highl...

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Veröffentlicht in:	Journal of neuroimmunology 2016-02, Vol.291, p.29-38
Hauptverfasser:	Madeira, Alexandra, Burgelin, Ingrid, Perron, Hervé, Curtin, Francois, Lang, Alois B, Faucard, Raphael
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Monoclonal, Humanized - pharmacology Brain - pathology Cell Differentiation - drug effects Cells, Cultured Cytokines - metabolism Endogenous Retroviruses - genetics Female Gene Products, env - genetics Gene Products, env - metabolism GNbAC1 HERV-W Humans Immunosuppressive Agents - pharmacology Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - adverse effects Mice Mice, Inbred C57BL Monoclonal antibody MSRV envelope Multiple sclerosis Multiple Sclerosis - pathology Neurology Oligodendroglia - drug effects Retroviridae Signal Transduction - drug effects Stem Cells - drug effects Time Factors TLR4 Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
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