In vivo micronucleus test in the assessment of cytogenotoxicity of landfill leachates in three animal models from various ecological habitats
The in vivo micronucleus (MN) test, a standard test for the genotoxicity screening of xenobiotics, was used to evaluate the cytotoxic and genotoxic activities of landfill leachates in Clarias gariepinus, Coturnix coturnix japonica and Rattus norvegicus. These organisms were exposed to various sub-le...
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| Veröffentlicht in: | Ecotoxicology (London) 2016-03, Vol.25 (2), p.310-319 |
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| creator | Alimba, Chibuisi G Bakare, Adekunle A |
| description | The in vivo micronucleus (MN) test, a standard test for the genotoxicity screening of xenobiotics, was used to evaluate the cytotoxic and genotoxic activities of landfill leachates in Clarias gariepinus, Coturnix coturnix japonica and Rattus norvegicus. These organisms were exposed to various sub-lethal concentrations (1–50 %) of Olusosun and Aba Eku landfill leachates. At post exposure, peripheral erythrocytes from catfish and quail, and bone marrow cells of quail and rat were subjected to MN analysis following standard protocols. The leachates induced significant increase in MN formation and total nuclear abnormalities (NAs) in the peripheral erythrocytes of catfish and quail. NAs occurred in the order; BN > BL > LB > NT in the catfish and BN > BudN > TLN > TN in quail. There was significant increase in MN formation in the bone marrow cells of quail, and micronucleated polychromatic erythrocytes and micronucleated normochromatic erythrocytes formation in the bone marrow of rats. The concentration dependent significant (p |
| doi_str_mv | 10.1007/s10646-015-1589-3 |
| format | Article |
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These organisms were exposed to various sub-lethal concentrations (1–50 %) of Olusosun and Aba Eku landfill leachates. At post exposure, peripheral erythrocytes from catfish and quail, and bone marrow cells of quail and rat were subjected to MN analysis following standard protocols. The leachates induced significant increase in MN formation and total nuclear abnormalities (NAs) in the peripheral erythrocytes of catfish and quail. NAs occurred in the order; BN > BL > LB > NT in the catfish and BN > BudN > TLN > TN in quail. There was significant increase in MN formation in the bone marrow cells of quail, and micronucleated polychromatic erythrocytes and micronucleated normochromatic erythrocytes formation in the bone marrow of rats. The concentration dependent significant (p < 0.05) decrease in the PCE/NCE ratio in the bone marrow of the leachate treated rats suggest alterations in the bone marrow cell proliferation, leading to the suppression of immature erythrocytes (PCE). MN induction showed positive corrections with leachate concentrations in the test organisms; and it increased with exposure duration in the catfish. Indiscriminate disposal of solid waste generates leachates containing multiple xenobiotics that are capable of increasing genomic instability among vertebrates inhabiting various ecological habitats.</description><identifier>ISSN: 0963-9292</identifier><identifier>EISSN: 1573-3017</identifier><identifier>DOI: 10.1007/s10646-015-1589-3</identifier><identifier>PMID: 26589948</identifier><identifier>CODEN: ECOTEL</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Animal models ; Animals ; bone formation ; Bone marrow ; bone marrow cells ; catfish ; Catfishes - metabolism ; cell proliferation ; Clarias gariepinus ; Coturnix - metabolism ; Coturnix coturnix japonica ; Coturnix japonica ; cytotoxicity ; Cytotoxins - toxicity ; Earth and Environmental Science ; Ecology ; Ecotoxicology ; Environment ; Environmental Management ; Erythrocytes ; exposure duration ; Fishes ; Genotoxicity ; habitats ; landfill leachates ; Landfills ; Leachates ; Micronucleus Tests ; Mutagens - toxicity ; Nigeria ; quails ; Rats ; Rats, Wistar ; Rattus norvegicus ; screening ; Solid waste disposal ; Solid wastes ; Test organisms ; Waste disposal sites ; Water Pollutants, Chemical - toxicity ; Xenobiotics</subject><ispartof>Ecotoxicology (London), 2016-03, Vol.25 (2), p.310-319</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-60f7a41cbc7883f866fae8bb13dec3e3f0ea3bd2b5bd4a07ad48cf9296e64dc63</citedby><cites>FETCH-LOGICAL-c566t-60f7a41cbc7883f866fae8bb13dec3e3f0ea3bd2b5bd4a07ad48cf9296e64dc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10646-015-1589-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10646-015-1589-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26589948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alimba, Chibuisi G</creatorcontrib><creatorcontrib>Bakare, Adekunle A</creatorcontrib><title>In vivo micronucleus test in the assessment of cytogenotoxicity of landfill leachates in three animal models from various ecological habitats</title><title>Ecotoxicology (London)</title><addtitle>Ecotoxicology</addtitle><addtitle>Ecotoxicology</addtitle><description>The in vivo micronucleus (MN) test, a standard test for the genotoxicity screening of xenobiotics, was used to evaluate the cytotoxic and genotoxic activities of landfill leachates in Clarias gariepinus, Coturnix coturnix japonica and Rattus norvegicus. These organisms were exposed to various sub-lethal concentrations (1–50 %) of Olusosun and Aba Eku landfill leachates. At post exposure, peripheral erythrocytes from catfish and quail, and bone marrow cells of quail and rat were subjected to MN analysis following standard protocols. The leachates induced significant increase in MN formation and total nuclear abnormalities (NAs) in the peripheral erythrocytes of catfish and quail. NAs occurred in the order; BN > BL > LB > NT in the catfish and BN > BudN > TLN > TN in quail. There was significant increase in MN formation in the bone marrow cells of quail, and micronucleated polychromatic erythrocytes and micronucleated normochromatic erythrocytes formation in the bone marrow of rats. The concentration dependent significant (p < 0.05) decrease in the PCE/NCE ratio in the bone marrow of the leachate treated rats suggest alterations in the bone marrow cell proliferation, leading to the suppression of immature erythrocytes (PCE). MN induction showed positive corrections with leachate concentrations in the test organisms; and it increased with exposure duration in the catfish. Indiscriminate disposal of solid waste generates leachates containing multiple xenobiotics that are capable of increasing genomic instability among vertebrates inhabiting various ecological habitats.</description><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>bone formation</subject><subject>Bone marrow</subject><subject>bone marrow cells</subject><subject>catfish</subject><subject>Catfishes - metabolism</subject><subject>cell proliferation</subject><subject>Clarias gariepinus</subject><subject>Coturnix - metabolism</subject><subject>Coturnix coturnix japonica</subject><subject>Coturnix japonica</subject><subject>cytotoxicity</subject><subject>Cytotoxins - toxicity</subject><subject>Earth and Environmental Science</subject><subject>Ecology</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Management</subject><subject>Erythrocytes</subject><subject>exposure duration</subject><subject>Fishes</subject><subject>Genotoxicity</subject><subject>habitats</subject><subject>landfill leachates</subject><subject>Landfills</subject><subject>Leachates</subject><subject>Micronucleus Tests</subject><subject>Mutagens - toxicity</subject><subject>Nigeria</subject><subject>quails</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rattus norvegicus</subject><subject>screening</subject><subject>Solid waste disposal</subject><subject>Solid wastes</subject><subject>Test organisms</subject><subject>Waste disposal sites</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Xenobiotics</subject><issn>0963-9292</issn><issn>1573-3017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kstu1DAUhi0EosPAA7ABS2zYpNhx4iTLquJSqRIL6NpynOMZV45dbM-IeQjemROlXIWQF5Z8vv_4PxdCnnN2zhnr3mTOZCMrxtuKt_1QiQdkw9tOVILx7iHZsEGKaqiH-ow8yfmWMTZ0DXtMzmqJ-ND0G_LtKtCjO0Y6O5NiOBgPh0wL5EJdoGUPVOcMOc8QCo2WmlOJOwixxK_OuHJa3rwOk3XeUw_a7DWKV20CVAc3a0_nOIHP1KY406NOLuInYKKPO2cwvNejK7rkp-SR1T7Ds_t7S27evf18-aG6_vj-6vLiujKtlKWSzHa64WY0Xd8L20tpNfTjyMUERoCwDLQYp3psx6nRrNNT0xuLjZAgm8lIsSWv17x3KX45YLFqdtmAx0oArSneyb7tWtHXiL76C72NhxTQ3UI1Q8tk3f-idtqDcsHGkrRZkqqLjosOOUy3Jef_oPBMgO2PAbCL8KeArwKcTc4JrLpL2M90UpypZQXUugIKV0AtK6AEal7cGz6MM0w_FT9mjkC9AhlDYQfpt4r-k_XlKrI6Kr1LLqubTzXjkjEuOEfL3wGG1sdS</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Alimba, Chibuisi G</creator><creator>Bakare, Adekunle A</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7SN</scope><scope>7ST</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>SOI</scope></search><sort><creationdate>20160301</creationdate><title>In vivo micronucleus test in the assessment of cytogenotoxicity of landfill leachates in three animal models from various ecological habitats</title><author>Alimba, Chibuisi G ; Bakare, Adekunle A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-60f7a41cbc7883f866fae8bb13dec3e3f0ea3bd2b5bd4a07ad48cf9296e64dc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Animal models</topic><topic>Animals</topic><topic>bone formation</topic><topic>Bone marrow</topic><topic>bone marrow cells</topic><topic>catfish</topic><topic>Catfishes - 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toxicity</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alimba, Chibuisi G</creatorcontrib><creatorcontrib>Bakare, Adekunle A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Ecology Abstracts</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><jtitle>Ecotoxicology (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alimba, Chibuisi G</au><au>Bakare, Adekunle A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo micronucleus test in the assessment of cytogenotoxicity of landfill leachates in three animal models from various ecological habitats</atitle><jtitle>Ecotoxicology (London)</jtitle><stitle>Ecotoxicology</stitle><addtitle>Ecotoxicology</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>25</volume><issue>2</issue><spage>310</spage><epage>319</epage><pages>310-319</pages><issn>0963-9292</issn><eissn>1573-3017</eissn><coden>ECOTEL</coden><abstract>The in vivo micronucleus (MN) test, a standard test for the genotoxicity screening of xenobiotics, was used to evaluate the cytotoxic and genotoxic activities of landfill leachates in Clarias gariepinus, Coturnix coturnix japonica and Rattus norvegicus. These organisms were exposed to various sub-lethal concentrations (1–50 %) of Olusosun and Aba Eku landfill leachates. At post exposure, peripheral erythrocytes from catfish and quail, and bone marrow cells of quail and rat were subjected to MN analysis following standard protocols. The leachates induced significant increase in MN formation and total nuclear abnormalities (NAs) in the peripheral erythrocytes of catfish and quail. NAs occurred in the order; BN > BL > LB > NT in the catfish and BN > BudN > TLN > TN in quail. There was significant increase in MN formation in the bone marrow cells of quail, and micronucleated polychromatic erythrocytes and micronucleated normochromatic erythrocytes formation in the bone marrow of rats. The concentration dependent significant (p < 0.05) decrease in the PCE/NCE ratio in the bone marrow of the leachate treated rats suggest alterations in the bone marrow cell proliferation, leading to the suppression of immature erythrocytes (PCE). MN induction showed positive corrections with leachate concentrations in the test organisms; and it increased with exposure duration in the catfish. Indiscriminate disposal of solid waste generates leachates containing multiple xenobiotics that are capable of increasing genomic instability among vertebrates inhabiting various ecological habitats.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26589948</pmid><doi>10.1007/s10646-015-1589-3</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Complete Journals |
| subjects | Analysis Animal models Animals bone formation Bone marrow bone marrow cells catfish Catfishes - metabolism cell proliferation Clarias gariepinus Coturnix - metabolism Coturnix coturnix japonica Coturnix japonica cytotoxicity Cytotoxins - toxicity Earth and Environmental Science Ecology Ecotoxicology Environment Environmental Management Erythrocytes exposure duration Fishes Genotoxicity habitats landfill leachates Landfills Leachates Micronucleus Tests Mutagens - toxicity Nigeria quails Rats Rats, Wistar Rattus norvegicus screening Solid waste disposal Solid wastes Test organisms Waste disposal sites Water Pollutants, Chemical - toxicity Xenobiotics |
| title | In vivo micronucleus test in the assessment of cytogenotoxicity of landfill leachates in three animal models from various ecological habitats |
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