The immunomodulator AS101 suppresses production of inflammatory cytokines and ameliorates the pathogenesis of experimental autoimmune encephalomyelitis

Abstract We reported that AS101 (organotellurium compound, trichloro(dioxoethylene- O , O ′) tellurate) inhibited the differentiation of Th17 cells and reduced the production of IL-17 and GM-CSF. In addition, AS101 promoted the production of IL-2 in activated T cells. Flow cytometric analysis showed...

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Veröffentlicht in:	Journal of neuroimmunology 2014-08, Vol.273 (1), p.31-41
Hauptverfasser:	Xie, Li, Chen, Jing, McMickle, Anthony, Awar, Nadia, Nady, Soad, Sredni, Benjamin, Drew, Paul D, Yu, Shiguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Cell Polarity - drug effects Cell Proliferation - drug effects Cytokines - biosynthesis Cytokines - immunology Cytokines - metabolism Disease Models, Animal Dose-Response Relationship, Drug Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - pathology Ethylenes - pharmacology Ethylenes - therapeutic use Female Freund's Adjuvant - pharmacology GM-CSF IL-17 Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Inflammation Mice Mice, Inbred C57BL Myelin-Oligodendrocyte Glycoprotein - pharmacology Neurology Oncogene Protein v-akt - metabolism Peptide Fragments - pharmacology Signal transduction Signal Transduction - drug effects Signal Transduction - immunology Spinal Cord - pathology Stat3 Th17 cells Th17 Cells - drug effects
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