Drug-induced Liver Fibrosis: Testing Nevirapine in a Viral-like Liver Setting Using Histopathology, MALDI IMS, and Gene Expression

Nevirapine (NVP) is associated with hepatotoxicity in 1–5% of patients. In rodent studies, NVP has been shown to cause hepatic enzyme induction, centrilobular hypertrophy, and skin rash in various rat strains but not liver toxicity. In an effort to understand whether NVP is metabolized differently i...

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Veröffentlicht in:	Toxicologic pathology 2016-01, Vol.44 (1), p.112-131
Hauptverfasser:	Brown, H. Roger, Castellino, Stephen, Groseclose, M. Reid, Elangbam, Chandikumar S., Mellon-Kusibab, Kathryn, Yoon, Lawrence W., Gates, Lisa D., Krull, David L., Cariello, Neal F., Arrington-Brown, Leigh, Tillman, Tony, Fowler, Serita, Shah, Vishal, Bailey, David, Miller, Richard T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - toxicity Female Galactosamine - toxicity Gene Expression Profiling Hepatitis C virus Histocytochemistry Liver - pathology Liver - virology Liver Cirrhosis - chemically induced Liver Cirrhosis - pathology Nevirapine - toxicity Rats Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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