High Glucose Increases the Expression of Inflammatory Cytokine Genes in Macrophages Through H3K9 Methyltransferase Mechanism

Recent studies suggest that histone modification is one of the mechanisms regulating inflammatory cytokine gene expression in hyperglycemic conditions. However, it remains unknown how histone methylation is initiated and involved in changes of inflammatory cytokine gene expression under high glucose...

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Veröffentlicht in:	Journal of interferon & cytokine research 2016-01, Vol.36 (1), p.48-61
Hauptverfasser:	Li, Mei-Fang, Zhang, Rong, Li, Ting-Ting, Chen, Ming-Yun, Li, Lian-Xi, Lu, Jun-Xi, Jia, Wei-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Chemokine CCL3 - agonists Chemokine CCL3 - genetics Chemokine CCL3 - immunology Chemokine CCL4 - agonists Chemokine CCL4 - genetics Chemokine CCL4 - immunology Enzyme Inhibitors - pharmacology Epigenesis, Genetic Gene Expression Profiling Glucose - pharmacology Histone-Lysine N-Methyltransferase - antagonists & inhibitors Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - immunology Histones - genetics Histones - immunology Humans Interleukin-12 Subunit p40 - agonists Interleukin-12 Subunit p40 - genetics Interleukin-12 Subunit p40 - immunology Interleukin-6 - agonists Interleukin-6 - genetics Interleukin-6 - immunology Macrophages - cytology Macrophages - drug effects Macrophages - immunology Male Methylation Mice Mice, Inbred C57BL Piperazines - pharmacology Primary Cell Culture Promoter Regions, Genetic Protein Array Analysis Signal Transduction
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