Role of immune tolerance in BALB/c mice with anaphylactic shock after Echinococcus granulosus infection

This study tested the hypothesis that immune tolerance mediated by regulatory T (Treg) cells is protective against cystic echinococcosis (CE)-induced anaphylactic shock. BALB/c mice were inoculated with protoscoleces of Echinococcus granulosus . After 3 months, the presence of cysts in the peritonea...

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Veröffentlicht in:	Immunologic research 2016-02, Vol.64 (1), p.233-241
Hauptverfasser:	Zhang, Qin, Ye, Jian-Rong, Ma, Hai-Mei, Wu, Jian-Jiang, Jiang, Tao, Zheng, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Allergology Anaphylaxis - immunology Animals Biomedical and Life Sciences Biomedicine Cellular biology Cytokines - metabolism Echinococcosis - immunology Echinococcus granulosus Echinococcus granulosus - immunology Female Forkhead Transcription Factors - metabolism Histamine - metabolism Immune Tolerance Immunization Immunoglobulin E - blood Immunology Interleukin-2 Receptor alpha Subunit - metabolism Internal Medicine Medicine/Public Health Mice Mice, Inbred BALB C Original Article Rodents Studies T-Lymphocytes, Regulatory - immunology
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Zusammenfassung:	This study tested the hypothesis that immune tolerance mediated by regulatory T (Treg) cells is protective against cystic echinococcosis (CE)-induced anaphylactic shock. BALB/c mice were inoculated with protoscoleces of Echinococcus granulosus . After 3 months, the presence of cysts in the peritoneal cavity was confirmed after which a subset of mice was sensitized using a cyst fluid suspension to induce anaphylactic shock. While IgE levels were significantly higher in both groups inoculated with E. granulosus as compared to the healthy control group (both P
ISSN:	0257-277X 1559-0755
DOI:	10.1007/s12026-015-8741-2