Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

Impairment of cognitive function is a common feature of many neurodevelopmental disorders. Systems genetics analysis in the brain uncovered a convergent gene network for both cognition and neurodevelopmental disorders. As the network does not recapitulate known pathways, this finding represents a ne...

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Veröffentlicht in:	Nature neuroscience 2016-02, Vol.19 (2), p.223-232
Hauptverfasser:	Johnson, Michael R, Shkura, Kirill, Langley, Sarah R, Delahaye-Duriez, Andree, Srivastava, Prashant, Hill, W David, Rackham, Owen J L, Davies, Gail, Harris, Sarah E, Moreno-Moral, Aida, Rotival, Maxime, Speed, Doug, Petrovski, Slavé, Katz, Anaïs, Hayward, Caroline, Porteous, David J, Smith, Blair H, Padmanabhan, Sandosh, Hocking, Lynne J, Starr, John M, Liewald, David C, Visconti, Alessia, Falchi, Mario, Bottolo, Leonardo, Rossetti, Tiziana, Danis, Bénédicte, Mazzuferi, Manuela, Foerch, Patrik, Grote, Alexander, Helmstaedter, Christoph, Becker, Albert J, Kaminski, Rafal M, Deary, Ian J, Petretto, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/39 45/43 49 49/91 631/114/2114 631/378/1689/2608 631/553 Analysis Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedicine Brain Chemistry - genetics Brain research Cognition Cognition & reasoning Cognitive ability Cognitive disorders Developmental Disabilities - genetics Developmental Disabilities - physiopathology Developmental Disabilities - psychology Disease Epidemiology Epilepsy Epilepsy, Temporal Lobe - genetics Epilepsy, Temporal Lobe - surgery Gene Expression Gene Regulatory Networks - genetics Genetic aspects Genetic markers Genetic Variation Genetics Genome-Wide Association Study Genomes Health sciences Hippocampus - surgery Humans Intellectual disabilities Medicine Memory Nervous System - growth & development Nervous System - physiopathology Nervous system diseases Neurobiology Neurosciences Synapses - genetics
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