Antimicrobial Activity of Plectasin NZ2114 in Combination with Cell Wall Targeting Antibiotics Against VanA-Type Enterococcus faecalis

Antimicrobial peptide plectasin targeting bacterial cell wall precursor Lipid II has been reported to be active against benzylpenicillin-resistant Streptococcus pneumoniae but less potent against vancomycin-resistant enterococci than their susceptible counterparts. The aim of this work was to test p...

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Veröffentlicht in:	Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2015-08, Vol.21 (4), p.373-379
Hauptverfasser:	Breidenstein, Elena B.M., Courvalin, Patrice, Meziane-Cherif, Djalal
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Bacteria - genetics Bacteria - ultrastructure Bacterial Proteins - genetics Carbon-Oxygen Ligases - genetics Cell Wall - drug effects Drug Combinations Drug resistance Drug Synergism Enterococcus faecalis Enterococcus faecalis - drug effects Mechanisms Microbial Sensitivity Tests Pathogens Peptides - pharmacology Streptococcus pneumoniae Synergism Vancomycin Resistance - genetics
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