KIR-HLA profiling shows presence of higher frequencies of strong inhibitory KIR-ligands among prognostically poor risk AML patients

The expression and interaction between killer cell immunoglobulin-like receptors (KIRs) and HLA are known to be associated with pathogenesis of diseases, including hematological malignancies. Presence of B haplotype KIR in donors is associated with a lower relapse risk for acute myeloid leukemia (AM...

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Veröffentlicht in:	Immunogenetics (New York) 2016-02, Vol.68 (2), p.133-144
Hauptverfasser:	Shen, Meixin, Linn, Yeh-Ching, Ren, Ee-Chee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Alleles Allergology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomedical and Life Sciences Biomedicine Case-Control Studies Cell Biology Chemotherapy Classification Cytotoxicity Disease Epistasis, Genetic Female Gene Frequency Gene Function Genetic Association Studies Haplotypes Hematopoietic Stem Cell Transplantation HLA Antigens - genetics Human Genetics Humans Immunology Leukemia Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - therapy Ligands Male Middle Aged Molecular Typing Original Article Prognosis Receptors, KIR - genetics Stem cells Surveillance Transplants & implants Treatment Outcome Young Adult
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