Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors

[Display omitted] Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor superfamily. Expression of ALK in normal human tissues is only found in a subset of neural cells, however it is involved in the genesis of several cancers through genetic aberrations in...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-02, Vol.26 (3), p.1090-1096
Hauptverfasser:	Michellys, Pierre-Yves, Chen, Bei, Jiang, Tao, Jin, Yunho, Lu, Wenshuo, Marsilje, Thomas H., Pei, Wei, Uno, Tetsuo, Zhu, Xuefeng, Wu, Baogen, Nguyen, Truc Ngoc, Bursulaya, Badry, Lee, Christian, Li, Nanxin, Kim, Sungjoon, Tuntland, Tove, Liu, Bo, Sun, Frank, Steffy, Auzon, Hood, Tami
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - analogs & derivatives 4-Aminopyridine - chemistry ALK Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Binding Sites Cell Line, Tumor Crystallography, X-Ray Drug Design Half-Life Hinge Humans Karpas299 Lymphoma, Large-Cell, Anaplastic - drug therapy Mice Mice, SCID Microsomes, Liver - metabolism Molecular Dynamics Simulation Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - pharmacokinetics Protein Kinase Inhibitors - therapeutic use Protein Structure, Tertiary Rats Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - metabolism Scaffold morphing Structure-Activity Relationship Transplantation, Heterologous
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