XPD, APE1, and MUTYH polymorphisms increase head and neck cancer risk: effect of gene-gene and gene-environment interactions

In the present study, we investigated the effect of the DNA repair gene polymorphisms XPD Asp312Asn (G>A), APE1 Asp148Glu (T>G), and MUTYH Tyr165Cys (G>A) on the risk for head and neck cancer (HNC) in association with tobacco use in a population of Northeast India. The study subjects compri...

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Veröffentlicht in:	Tumor biology 2015-09, Vol.36 (10), p.7569-7579
Hauptverfasser:	Das, Sambuddha, Bhowmik, Aditi, Bhattacharjee, Abhinandan, Choudhury, Biswadeep, Naiding, Momota, Laskar, Agniv Kr, Ghosh, Sankar Kumar, Choudhury, Yashmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Deoxyribonucleic acid DNA DNA Glycosylases - genetics DNA Repair - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics Female Gene-Environment Interaction Genetic Predisposition to Disease - genetics Genotype Head & neck cancer Head and Neck Neoplasms - genetics Humans India Male Middle Aged Polymorphism Polymorphism, Genetic - genetics Research Article Risk Risk Factors Smoking - genetics Studies Xeroderma Pigmentosum Group D Protein - genetics
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