miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells
Leukemic stem cells (LSCs) are resistant to conventional chemotherapy and promote acute myeloid leukemia (AML) progression and recurrence. In this issue of Cancer Cell, Lechman and colleagues (2016) identify the microRNA miR-126 as a regulator of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-ren...
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| Veröffentlicht in: | Cancer cell 2016-02, Vol.29 (2), p.133-135 |
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| container_title | Cancer cell |
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| creator | Raffel, Simon Trumpp, Andreas |
| description | Leukemic stem cells (LSCs) are resistant to conventional chemotherapy and promote acute myeloid leukemia (AML) progression and recurrence. In this issue of Cancer Cell, Lechman and colleagues (2016) identify the microRNA miR-126 as a regulator of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-renewal and chemotherapy resistance.
Leukemic stem cells (LSCs) are resistant to conventional chemotherapy and promote acute myeloid leukemia (AML) progression and recurrence. In this issue of Cancer Cell, Lechman and colleagues (2016) identify the microRNA miR-126 as a regulator of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-renewal and chemotherapy resistance. |
| doi_str_mv | 10.1016/j.ccell.2016.01.007 |
| format | Article |
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Leukemic stem cells (LSCs) are resistant to conventional chemotherapy and promote acute myeloid leukemia (AML) progression and recurrence. In this issue of Cancer Cell, Lechman and colleagues (2016) identify the microRNA miR-126 as a regulator of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-renewal and chemotherapy resistance.</description><subject>Animals</subject><subject>Hematopoietic Stem Cells - pathology</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>MicroRNAs - physiology</subject><issn>1535-6108</issn><issn>1878-3686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EoqXwBUjISzYJfiSxu2BRladUCdHC2nKcseSSR4mTIv4ehxaWiNXMSGfmag5C55TElNDsah0bA2UZszDEhMaEiAM0plLIiGcyOwx9ytMoo0SO0In3axJAKqbHaMQymU6TZDpGs8otI8oyfNO6LXj83DvwBmoDWNcFXkFpoyXU8KFL7Gq8gP4NKmfwqoMKz0O8P0VHVpcezvZ1gl7vbl_mD9Hi6f5xPltEJuGii0yuWSqBU6FlYrhOSA46ZyC5nQpubUGyRHJqNCdMSCMpM5YXWhSQU2sZ8Am63N3dtM17D75TlfODAF1D03tFRXgqE5KJ_6CJIFSmaUD5DjVt430LVm1aV-n2U1GiBs1qrb41q0GzIlQFzWHrYh_Q5xUUvzs_XgNwvQMgGNk6aJU3brBauBZMp4rG_RnwBZRQjTA</recordid><startdate>20160208</startdate><enddate>20160208</enddate><creator>Raffel, Simon</creator><creator>Trumpp, Andreas</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20160208</creationdate><title>miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells</title><author>Raffel, Simon ; Trumpp, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-cba258e317a84c3a40beab2e83f973ffd064831ca30278c812cf3da7deb1ff2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Hematopoietic Stem Cells - pathology</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>MicroRNAs - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raffel, Simon</creatorcontrib><creatorcontrib>Trumpp, Andreas</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raffel, Simon</au><au>Trumpp, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells</atitle><jtitle>Cancer cell</jtitle><addtitle>Cancer Cell</addtitle><date>2016-02-08</date><risdate>2016</risdate><volume>29</volume><issue>2</issue><spage>133</spage><epage>135</epage><pages>133-135</pages><issn>1535-6108</issn><eissn>1878-3686</eissn><abstract>Leukemic stem cells (LSCs) are resistant to conventional chemotherapy and promote acute myeloid leukemia (AML) progression and recurrence. In this issue of Cancer Cell, Lechman and colleagues (2016) identify the microRNA miR-126 as a regulator of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-renewal and chemotherapy resistance.
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Hematopoietic Stem Cells - pathology Humans Leukemia, Myeloid, Acute - pathology MicroRNAs - physiology |
| title | miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells |
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