Bone Morphogenic Protein 4-Smad–Induced Upregulation of Platelet-Derived Growth Factor AA Impairs Endothelial Function

OBJECTIVE—Bone morphogenic protein 4 (BMP4) is an important mediator of endothelial dysfunction in cardio-metabolic diseases, whereas platelet-derived growth factors (PDGFs) are major angiogenic and proinflammatory mediator, although the functional link between these 2 factors is unknown. The presen...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2016-03, Vol.36 (3), p.553-560
Hauptverfasser:	Hu, Weining, Zhang, Yang, Wang, Li, Lau, Chi Wai, Xu, Jian, Luo, Jiang-Yun, Gou, Lingshan, Yao, Xiaoqiang, Chen, Zhen-Yu, Ma, Ronald Ching Wan, Tian, Xiao Yu, Huang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antibodies, Neutralizing - pharmacology Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Bone Morphogenetic Protein 4 - pharmacology Case-Control Studies Cells, Cultured Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Humans Male Mice Mice, Inbred C57BL Middle Aged Platelet-Derived Growth Factor - antagonists & inhibitors Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology Receptor, Platelet-Derived Growth Factor alpha - genetics Receptor, Platelet-Derived Growth Factor alpha - metabolism RNA Interference Signal Transduction - drug effects Smad Proteins, Receptor-Regulated - genetics Smad Proteins, Receptor-Regulated - metabolism Time Factors Tissue Culture Techniques Transfection Up-Regulation Vasodilation - drug effects Vasodilator Agents - pharmacology
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