Tacrolimus interaction with dexmedetomidine—a case report

Drugs and xenobiotics that inhibit the CYP‐450 isoenzyme 3A4 are associated with increased serum tacrolimus levels. We sought to determine whether there was a temporal association between initiation of dexmedetomidine and increased serum tacrolimus levels. An interaction has not been previously docu...

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Veröffentlicht in:	Pediatric transplantation 2016-02, Vol.20 (1), p.155-157
Hauptverfasser:	Stiehl, Sarah R., Squires, James E., Bucuvalas, John C., Hemmelgarn, Trina S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Agonists - administration & dosage Biliary Atresia - surgery Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - adverse effects Cytochrome P-450 CYP3A - chemistry dexmedetomidine Dexmedetomidine - administration & dosage Dexmedetomidine - adverse effects Drug Interactions Female Humans Immunosuppressive Agents - administration & dosage Infant Liver - metabolism Liver Transplantation pediatric liver transplantation tacrolimus Tacrolimus - administration & dosage Tacrolimus - adverse effects Tacrolimus - blood therapeutic drug monitoring Time Factors
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