Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, [alpha]-aminoadipic acid pool and penicillin production

Homocitrate synthase activity (encoded by the lys1 gene) catalyzes the first step of the lysine and penicillin pathway and is highly sensitive to feedback regulation by l-lysine. The transcript levels of the lys1 gene and the homocitrate synthase activity are high during the growth phase and decreas...

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Veröffentlicht in:	Applied microbiology and biotechnology 2000-07, Vol.54 (1), p.69-77
Hauptverfasser:	Bañuelos, O, Casqueiro, J, Gutiérrez, S, Martín, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	a-Aminoadipic acid aminoadipic acid lys1 gene Penicillin Penicillium chrysogenum
Online-Zugang:	Volltext
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