n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus

Apoptosis of hypothalamic neurons is believed to play an important role in the development and perpetuation of obesity. Similar to the hippocampus, the hypothalamus presents constitutive and stimulated neurogenesis, suggesting that obesity-associated hypothalamic dysfunction can be repaired. Here, w...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2016-03, Vol.65 (3), p.673-686
Hauptverfasser:	Nascimento, Lucas F R, Souza, Gabriela F P, Morari, Joseane, Barbosa, Guilherme O, Solon, Carina, Moura, Rodrigo F, Victório, Sheila C, Ignácio-Souza, Letícia M, Razolli, Daniela S, Carvalho, Hernandes F, Velloso, Lício A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blood Glucose - drug effects Blood Glucose - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - drug effects Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Diabetes Fatty acids Fatty Acids, Omega-3 - pharmacology Glucose Tolerance Test Hypothalamus - cytology Hypothalamus - drug effects Hypothalamus - metabolism Mice Neurogenesis - drug effects Neurons Neurons - drug effects Neurons - metabolism Neuropeptide Y Obesity Pro-Opiomelanocortin - metabolism Real-Time Polymerase Chain Reaction Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - metabolism
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