p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

The intermediate filament protein keratin 17 (Krt17) shows highly dynamic and inducible expression in skin physiology and pathology. Because Krt17 exerts physiologically important functions beyond providing structural stability to keratinocytes whereas abnormal Krt17 expression is a key feature of d...

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Veröffentlicht in:	Journal of investigative dermatology 2016-03, Vol.136 (3), p.680-689
Hauptverfasser:	Liao, Chunyan, Xie, Guojiang, Zhu, Liyan, Chen, Xi, Li, Xiaobo, Lu, Haijie, Xu, Benhua, Ramot, Yuval, Paus, Ralf, Yue, Zhicao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal DNA Damage Down-Regulation Gene Expression Regulation Immunohistochemistry Keratins - genetics Mice Mice, Inbred C57BL Polymerase Chain Reaction - methods Promoter Regions, Genetic Protein Binding Radiodermatitis - genetics Radiodermatitis - pathology Random Allocation Rats Rats, Wistar Sensitivity and Specificity Tumor Suppressor Protein p53 - metabolism
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