Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients
Background: Total joint arthroplasty (TJA) patients are mostly of advanced age and with comorbidities such as increased body mass index (BMI) and impaired glucose tolerance. These factors and type of surgery may affect the fibrinolytic system. Aim: To investigate the effect of age, sex, BMI, type of...
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| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2016-04, Vol.22 (3), p.274-279 |
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| creator | Burleson, Andrew Guler, Nil Banos, Andrew Syed, Daneyal Wanderling, Christopher Hoppensteadt, Debra Rees, Harold Fareed, Jawed Hopkinson, William |
| description | Background:
Total joint arthroplasty (TJA) patients are mostly of advanced age and with comorbidities such as increased body mass index (BMI) and impaired glucose tolerance. These factors and type of surgery may affect the fibrinolytic system.
Aim:
To investigate the effect of age, sex, BMI, type of surgery, and tranexamic acid (TXA) treatment on the fibrinolytic system in TJA patients.
Methods:
Ninety-nine patients undergoing TJA (32 total hip arthroplasty [THA] and 67 total knee arthroplasty [TKA]) were included in this study. Blood samples were drawn at preoperative clinic appointments and on postoperative day 1. Antigenic levels of d-dimer, plasminogen activator inhibitor 1 (PAI-1), and tissue plasminogen activator (tPA) were measured using a commercially available enzyme-linked immunosorbent assay kit. Antiplasmin activity was measured using functional method. Age, gender, hemoglobin (Hb) levels, and BMI were collected from the records.
Results:
Preoperative d-dimer and tPA levels were positively correlated with age, whereas preoperative antiplasmin was negatively correlated with age. Body mass index was only associated with preoperative tPA levels. There was no significant difference in postoperative levels of d-dimer, PAI-1, tPA, or antiplasmin between patients treated with TXA or without TXA. Percentage change in d-dimer and tPA showed significantly lower values in patients treated with TXA compared to the nontreated group. Type of surgery did not affect the fibrinolytic markers.
Conclusion:
These results confirm that advanced age and elevated BMI positively contribute to fibrinolytic dysregulation in TJA patients, whereas TXA seems to decrease the fibrinolytic activity. |
| doi_str_mv | 10.1177/1076029615611251 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_proquest_miscellaneous_1767912453</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1076029615611251</sage_id><sourcerecordid>2344182578</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-d5af3438f187cf88a49a6e55e51203742552dc128bd58850bd87cc135fea5df93</originalsourceid><addsrcrecordid>eNp1kM1rGzEQxUVoSNK0956KoJdeNtFIq489huC0hUAMSS65LLJ2VCusV64kF_zfV8ZOCoGcZuD93pvhEfIF2AWA1pfAtGK8UyAVAJdwRM6gE6bhmosPda9ys9NPycecnxmDTnXqhJxy1SomhDwjT3NMIa4x2RL-Ir2xrsSUqZ0G-rDEkOjMe3SFxomWZdXDIoUpjtsSHL3f5oIrGiZ6lcoyxfVoc9nSeY3CqeRP5NjbMePnwzwnjzezh-ufze3dj1_XV7eNa5kuzSCtF60wHox23hjbdlahlCiBM6FbLiUfHHCzGKQxki2GyjkQ0qOVg-_EOfm-z12n-GeDufSrkB2Oo50wbnIPWukOeCtFRb-9QZ_jJk31u56LtgXDpTaVYnvKpZhzQt-vU1jZtO2B9bve-7e9V8vXQ_BmscLh1fBSdAWaPZDtb_x_9d3Af9VNiVE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2344182578</pqid></control><display><type>article</type><title>Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients</title><source>Sage Journals GOLD Open Access 2024</source><creator>Burleson, Andrew ; Guler, Nil ; Banos, Andrew ; Syed, Daneyal ; Wanderling, Christopher ; Hoppensteadt, Debra ; Rees, Harold ; Fareed, Jawed ; Hopkinson, William</creator><creatorcontrib>Burleson, Andrew ; Guler, Nil ; Banos, Andrew ; Syed, Daneyal ; Wanderling, Christopher ; Hoppensteadt, Debra ; Rees, Harold ; Fareed, Jawed ; Hopkinson, William</creatorcontrib><description>Background:
Total joint arthroplasty (TJA) patients are mostly of advanced age and with comorbidities such as increased body mass index (BMI) and impaired glucose tolerance. These factors and type of surgery may affect the fibrinolytic system.
Aim:
To investigate the effect of age, sex, BMI, type of surgery, and tranexamic acid (TXA) treatment on the fibrinolytic system in TJA patients.
Methods:
Ninety-nine patients undergoing TJA (32 total hip arthroplasty [THA] and 67 total knee arthroplasty [TKA]) were included in this study. Blood samples were drawn at preoperative clinic appointments and on postoperative day 1. Antigenic levels of d-dimer, plasminogen activator inhibitor 1 (PAI-1), and tissue plasminogen activator (tPA) were measured using a commercially available enzyme-linked immunosorbent assay kit. Antiplasmin activity was measured using functional method. Age, gender, hemoglobin (Hb) levels, and BMI were collected from the records.
Results:
Preoperative d-dimer and tPA levels were positively correlated with age, whereas preoperative antiplasmin was negatively correlated with age. Body mass index was only associated with preoperative tPA levels. There was no significant difference in postoperative levels of d-dimer, PAI-1, tPA, or antiplasmin between patients treated with TXA or without TXA. Percentage change in d-dimer and tPA showed significantly lower values in patients treated with TXA compared to the nontreated group. Type of surgery did not affect the fibrinolytic markers.
Conclusion:
These results confirm that advanced age and elevated BMI positively contribute to fibrinolytic dysregulation in TJA patients, whereas TXA seems to decrease the fibrinolytic activity.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/1076029615611251</identifier><identifier>PMID: 26460335</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Age ; Age Factors ; Aged ; Arthroplasty, Replacement, Hip ; Arthroplasty, Replacement, Knee ; Body Mass Index ; Female ; Fibrin Fibrinogen Degradation Products - metabolism ; Fibrinolysis ; Humans ; Joint surgery ; Male ; Middle Aged ; Perioperative Period ; Plasminogen Activator Inhibitor 1 - blood ; Sex Factors ; Surgery ; Tissue Plasminogen Activator - blood</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2016-04, Vol.22 (3), p.274-279</ispartof><rights>The Author(s) 2015</rights><rights>The Author(s) 2015.</rights><rights>The Author(s) 2015. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-d5af3438f187cf88a49a6e55e51203742552dc128bd58850bd87cc135fea5df93</citedby><cites>FETCH-LOGICAL-c407t-d5af3438f187cf88a49a6e55e51203742552dc128bd58850bd87cc135fea5df93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1076029615611251$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1076029615611251$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1076029615611251?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26460335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burleson, Andrew</creatorcontrib><creatorcontrib>Guler, Nil</creatorcontrib><creatorcontrib>Banos, Andrew</creatorcontrib><creatorcontrib>Syed, Daneyal</creatorcontrib><creatorcontrib>Wanderling, Christopher</creatorcontrib><creatorcontrib>Hoppensteadt, Debra</creatorcontrib><creatorcontrib>Rees, Harold</creatorcontrib><creatorcontrib>Fareed, Jawed</creatorcontrib><creatorcontrib>Hopkinson, William</creatorcontrib><title>Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>Background:
Total joint arthroplasty (TJA) patients are mostly of advanced age and with comorbidities such as increased body mass index (BMI) and impaired glucose tolerance. These factors and type of surgery may affect the fibrinolytic system.
Aim:
To investigate the effect of age, sex, BMI, type of surgery, and tranexamic acid (TXA) treatment on the fibrinolytic system in TJA patients.
Methods:
Ninety-nine patients undergoing TJA (32 total hip arthroplasty [THA] and 67 total knee arthroplasty [TKA]) were included in this study. Blood samples were drawn at preoperative clinic appointments and on postoperative day 1. Antigenic levels of d-dimer, plasminogen activator inhibitor 1 (PAI-1), and tissue plasminogen activator (tPA) were measured using a commercially available enzyme-linked immunosorbent assay kit. Antiplasmin activity was measured using functional method. Age, gender, hemoglobin (Hb) levels, and BMI were collected from the records.
Results:
Preoperative d-dimer and tPA levels were positively correlated with age, whereas preoperative antiplasmin was negatively correlated with age. Body mass index was only associated with preoperative tPA levels. There was no significant difference in postoperative levels of d-dimer, PAI-1, tPA, or antiplasmin between patients treated with TXA or without TXA. Percentage change in d-dimer and tPA showed significantly lower values in patients treated with TXA compared to the nontreated group. Type of surgery did not affect the fibrinolytic markers.
Conclusion:
These results confirm that advanced age and elevated BMI positively contribute to fibrinolytic dysregulation in TJA patients, whereas TXA seems to decrease the fibrinolytic activity.</description><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Arthroplasty, Replacement, Hip</subject><subject>Arthroplasty, Replacement, Knee</subject><subject>Body Mass Index</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - metabolism</subject><subject>Fibrinolysis</subject><subject>Humans</subject><subject>Joint surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Perioperative Period</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Sex Factors</subject><subject>Surgery</subject><subject>Tissue Plasminogen Activator - blood</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kM1rGzEQxUVoSNK0956KoJdeNtFIq489huC0hUAMSS65LLJ2VCusV64kF_zfV8ZOCoGcZuD93pvhEfIF2AWA1pfAtGK8UyAVAJdwRM6gE6bhmosPda9ys9NPycecnxmDTnXqhJxy1SomhDwjT3NMIa4x2RL-Ir2xrsSUqZ0G-rDEkOjMe3SFxomWZdXDIoUpjtsSHL3f5oIrGiZ6lcoyxfVoc9nSeY3CqeRP5NjbMePnwzwnjzezh-ufze3dj1_XV7eNa5kuzSCtF60wHox23hjbdlahlCiBM6FbLiUfHHCzGKQxki2GyjkQ0qOVg-_EOfm-z12n-GeDufSrkB2Oo50wbnIPWukOeCtFRb-9QZ_jJk31u56LtgXDpTaVYnvKpZhzQt-vU1jZtO2B9bve-7e9V8vXQ_BmscLh1fBSdAWaPZDtb_x_9d3Af9VNiVE</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Burleson, Andrew</creator><creator>Guler, Nil</creator><creator>Banos, Andrew</creator><creator>Syed, Daneyal</creator><creator>Wanderling, Christopher</creator><creator>Hoppensteadt, Debra</creator><creator>Rees, Harold</creator><creator>Fareed, Jawed</creator><creator>Hopkinson, William</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201604</creationdate><title>Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients</title><author>Burleson, Andrew ; Guler, Nil ; Banos, Andrew ; Syed, Daneyal ; Wanderling, Christopher ; Hoppensteadt, Debra ; Rees, Harold ; Fareed, Jawed ; Hopkinson, William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-d5af3438f187cf88a49a6e55e51203742552dc128bd58850bd87cc135fea5df93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Arthroplasty, Replacement, Hip</topic><topic>Arthroplasty, Replacement, Knee</topic><topic>Body Mass Index</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>Fibrinolysis</topic><topic>Humans</topic><topic>Joint surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Perioperative Period</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Sex Factors</topic><topic>Surgery</topic><topic>Tissue Plasminogen Activator - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burleson, Andrew</creatorcontrib><creatorcontrib>Guler, Nil</creatorcontrib><creatorcontrib>Banos, Andrew</creatorcontrib><creatorcontrib>Syed, Daneyal</creatorcontrib><creatorcontrib>Wanderling, Christopher</creatorcontrib><creatorcontrib>Hoppensteadt, Debra</creatorcontrib><creatorcontrib>Rees, Harold</creatorcontrib><creatorcontrib>Fareed, Jawed</creatorcontrib><creatorcontrib>Hopkinson, William</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Burleson, Andrew</au><au>Guler, Nil</au><au>Banos, Andrew</au><au>Syed, Daneyal</au><au>Wanderling, Christopher</au><au>Hoppensteadt, Debra</au><au>Rees, Harold</au><au>Fareed, Jawed</au><au>Hopkinson, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2016-04</date><risdate>2016</risdate><volume>22</volume><issue>3</issue><spage>274</spage><epage>279</epage><pages>274-279</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>Background:
Total joint arthroplasty (TJA) patients are mostly of advanced age and with comorbidities such as increased body mass index (BMI) and impaired glucose tolerance. These factors and type of surgery may affect the fibrinolytic system.
Aim:
To investigate the effect of age, sex, BMI, type of surgery, and tranexamic acid (TXA) treatment on the fibrinolytic system in TJA patients.
Methods:
Ninety-nine patients undergoing TJA (32 total hip arthroplasty [THA] and 67 total knee arthroplasty [TKA]) were included in this study. Blood samples were drawn at preoperative clinic appointments and on postoperative day 1. Antigenic levels of d-dimer, plasminogen activator inhibitor 1 (PAI-1), and tissue plasminogen activator (tPA) were measured using a commercially available enzyme-linked immunosorbent assay kit. Antiplasmin activity was measured using functional method. Age, gender, hemoglobin (Hb) levels, and BMI were collected from the records.
Results:
Preoperative d-dimer and tPA levels were positively correlated with age, whereas preoperative antiplasmin was negatively correlated with age. Body mass index was only associated with preoperative tPA levels. There was no significant difference in postoperative levels of d-dimer, PAI-1, tPA, or antiplasmin between patients treated with TXA or without TXA. Percentage change in d-dimer and tPA showed significantly lower values in patients treated with TXA compared to the nontreated group. Type of surgery did not affect the fibrinolytic markers.
Conclusion:
These results confirm that advanced age and elevated BMI positively contribute to fibrinolytic dysregulation in TJA patients, whereas TXA seems to decrease the fibrinolytic activity.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>26460335</pmid><doi>10.1177/1076029615611251</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1076-0296 |
| ispartof | Clinical and applied thrombosis/hemostasis, 2016-04, Vol.22 (3), p.274-279 |
| issn | 1076-0296 1938-2723 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Age Age Factors Aged Arthroplasty, Replacement, Hip Arthroplasty, Replacement, Knee Body Mass Index Female Fibrin Fibrinogen Degradation Products - metabolism Fibrinolysis Humans Joint surgery Male Middle Aged Perioperative Period Plasminogen Activator Inhibitor 1 - blood Sex Factors Surgery Tissue Plasminogen Activator - blood |
| title | Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients |
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