Heated humidified high flow nasal cannula versus nasal continuous positive airway pressure as primary mode of respiratory support for respiratory distress in preterm infants

Objective To compare the outcomes of preterm infants with respiratory distress initiated on either Heated Humidified High Flow Nasal Cannula or Nasal Continuous Positive Airway Pressure as a primary mode of respiratory support. Study Design Prospective observational cohort study Setting Tertiary car...

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Veröffentlicht in:Indian pediatrics 2016-02, Vol.53 (2), p.129-133
Hauptverfasser: Hegde, Deeparaj, Mondkar, Jayashree, Panchal, Harshad, Manerkar, Swati, Jasani, Bonny, Kabra, Nandkishor
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container_end_page 133
container_issue 2
container_start_page 129
container_title Indian pediatrics
container_volume 53
creator Hegde, Deeparaj
Mondkar, Jayashree
Panchal, Harshad
Manerkar, Swati
Jasani, Bonny
Kabra, Nandkishor
description Objective To compare the outcomes of preterm infants with respiratory distress initiated on either Heated Humidified High Flow Nasal Cannula or Nasal Continuous Positive Airway Pressure as a primary mode of respiratory support. Study Design Prospective observational cohort study Setting Tertiary care level III neonatal intensive care unit Participants 88 preterm infants between 28 to 34 weeks of gestation with mild to moderate respiratory distress within 6 hours of birth. Intervention Eligible infants were treated either with Heated Humidified High Flow Nasal Cannula ( n =46) or Nasal Continuous Positive Airway Pressure ( n =42). Primary outcome Need for mechanical ventilation within 72 hrs of initiating support. Results Baseline demographic characteristics were comparable between the two groups. There was no difference in the requirement of mechanical ventilation between Heated Humidified High Flow Nasal Cannula (19.5%) and Nasal Continuous Positive Airway Pressure (26.2%) groups [RD–0.74 (95% CI 0.34–1.62; P =0.46)]. Moderate or severe nasal trauma occurred less frequently with Heated Humidified High Flow Nasal Cannula (10.9%) in comparison to Nasal Continuous Positive Airway Pressure (40.5%) ( P = 0.004). Conclusion Heated Humidified High Flow Nasal Cannula was comparable to Nasal Continuous Positive Airway Pressure as a primary respiratory support for preterm infants with respiratory distress, with lesser incidence of nasal trauma.
doi_str_mv 10.1007/s13312-016-0806-3
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Study Design Prospective observational cohort study Setting Tertiary care level III neonatal intensive care unit Participants 88 preterm infants between 28 to 34 weeks of gestation with mild to moderate respiratory distress within 6 hours of birth. Intervention Eligible infants were treated either with Heated Humidified High Flow Nasal Cannula ( n =46) or Nasal Continuous Positive Airway Pressure ( n =42). Primary outcome Need for mechanical ventilation within 72 hrs of initiating support. Results Baseline demographic characteristics were comparable between the two groups. There was no difference in the requirement of mechanical ventilation between Heated Humidified High Flow Nasal Cannula (19.5%) and Nasal Continuous Positive Airway Pressure (26.2%) groups [RD–0.74 (95% CI 0.34–1.62; P =0.46)]. Moderate or severe nasal trauma occurred less frequently with Heated Humidified High Flow Nasal Cannula (10.9%) in comparison to Nasal Continuous Positive Airway Pressure (40.5%) ( P = 0.004). Conclusion Heated Humidified High Flow Nasal Cannula was comparable to Nasal Continuous Positive Airway Pressure as a primary respiratory support for preterm infants with respiratory distress, with lesser incidence of nasal trauma.</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>DOI: 10.1007/s13312-016-0806-3</identifier><identifier>PMID: 26897144</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Female ; Humans ; Humidity ; Infant, Newborn ; Infant, Premature ; Male ; Maternal and Child Health ; Medicine ; Medicine &amp; Public Health ; Nasal Cavity - injuries ; Pediatric Surgery ; Pediatrics ; Prospective Studies ; Research Paper ; Respiration, Artificial - adverse effects ; Respiration, Artificial - instrumentation ; Respiration, Artificial - methods ; Respiration, Artificial - statistics &amp; numerical data ; Respiratory Distress Syndrome, Newborn - epidemiology ; Respiratory Distress Syndrome, Newborn - therapy</subject><ispartof>Indian pediatrics, 2016-02, Vol.53 (2), p.129-133</ispartof><rights>Indian Academy of Pediatrics 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-f719c94f5685468fc6e2ae6773a8a7075c4aa5f4f5fb27632d9f924fdf432b943</citedby><cites>FETCH-LOGICAL-c344t-f719c94f5685468fc6e2ae6773a8a7075c4aa5f4f5fb27632d9f924fdf432b943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13312-016-0806-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13312-016-0806-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26897144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hegde, Deeparaj</creatorcontrib><creatorcontrib>Mondkar, Jayashree</creatorcontrib><creatorcontrib>Panchal, Harshad</creatorcontrib><creatorcontrib>Manerkar, Swati</creatorcontrib><creatorcontrib>Jasani, Bonny</creatorcontrib><creatorcontrib>Kabra, Nandkishor</creatorcontrib><title>Heated humidified high flow nasal cannula versus nasal continuous positive airway pressure as primary mode of respiratory support for respiratory distress in preterm infants</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><addtitle>Indian Pediatr</addtitle><description>Objective To compare the outcomes of preterm infants with respiratory distress initiated on either Heated Humidified High Flow Nasal Cannula or Nasal Continuous Positive Airway Pressure as a primary mode of respiratory support. Study Design Prospective observational cohort study Setting Tertiary care level III neonatal intensive care unit Participants 88 preterm infants between 28 to 34 weeks of gestation with mild to moderate respiratory distress within 6 hours of birth. Intervention Eligible infants were treated either with Heated Humidified High Flow Nasal Cannula ( n =46) or Nasal Continuous Positive Airway Pressure ( n =42). Primary outcome Need for mechanical ventilation within 72 hrs of initiating support. Results Baseline demographic characteristics were comparable between the two groups. There was no difference in the requirement of mechanical ventilation between Heated Humidified High Flow Nasal Cannula (19.5%) and Nasal Continuous Positive Airway Pressure (26.2%) groups [RD–0.74 (95% CI 0.34–1.62; P =0.46)]. Moderate or severe nasal trauma occurred less frequently with Heated Humidified High Flow Nasal Cannula (10.9%) in comparison to Nasal Continuous Positive Airway Pressure (40.5%) ( P = 0.004). 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Study Design Prospective observational cohort study Setting Tertiary care level III neonatal intensive care unit Participants 88 preterm infants between 28 to 34 weeks of gestation with mild to moderate respiratory distress within 6 hours of birth. Intervention Eligible infants were treated either with Heated Humidified High Flow Nasal Cannula ( n =46) or Nasal Continuous Positive Airway Pressure ( n =42). Primary outcome Need for mechanical ventilation within 72 hrs of initiating support. Results Baseline demographic characteristics were comparable between the two groups. There was no difference in the requirement of mechanical ventilation between Heated Humidified High Flow Nasal Cannula (19.5%) and Nasal Continuous Positive Airway Pressure (26.2%) groups [RD–0.74 (95% CI 0.34–1.62; P =0.46)]. Moderate or severe nasal trauma occurred less frequently with Heated Humidified High Flow Nasal Cannula (10.9%) in comparison to Nasal Continuous Positive Airway Pressure (40.5%) ( P = 0.004). 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subjects Female
Humans
Humidity
Infant, Newborn
Infant, Premature
Male
Maternal and Child Health
Medicine
Medicine & Public Health
Nasal Cavity - injuries
Pediatric Surgery
Pediatrics
Prospective Studies
Research Paper
Respiration, Artificial - adverse effects
Respiration, Artificial - instrumentation
Respiration, Artificial - methods
Respiration, Artificial - statistics & numerical data
Respiratory Distress Syndrome, Newborn - epidemiology
Respiratory Distress Syndrome, Newborn - therapy
title Heated humidified high flow nasal cannula versus nasal continuous positive airway pressure as primary mode of respiratory support for respiratory distress in preterm infants
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