MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1
Abstract Background The inhibition role of miRNA (microRNA or miR) on cancer signaling pathways has been used to prospective cancer treatment. SIRT1 might promote tumorigenesis in human glioma. Methods Here, we investigated whether miR-132 regulate the expression of SIRT1 and its downstream SREBP (S...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2016-03, Vol.78, p.177-184 |
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| creator | Li, Yunjun Zhang, Jinqian He, Jingliang Zhou, Wenjie Xiang, Guoan Xu, Ruxiang |
| description | Abstract Background The inhibition role of miRNA (microRNA or miR) on cancer signaling pathways has been used to prospective cancer treatment. SIRT1 might promote tumorigenesis in human glioma. Methods Here, we investigated whether miR-132 regulate the expression of SIRT1 and its downstream SREBP (Sterol regulatory element-binding protein)-lipogenesis-cholesterogenesis metabolic pathway in human glioma cells. Furthermore, we studied the effect on biology function of glioma cell induced by miR-132. Results MiR-132 inhibited SIRT1 and SREBP-1c expression and downregulated their targeted genes, including HMGCR and FASN. MiR-132 suppressed the cell growth, tumorigenicity, the invasion of glioma cells and migration as well as promoted their apoptosis. The pathways associated with cancer progression and tumorigenicity, and induce glioma cell apoptosis has been inhibited by miR-132 involving in a caspase-dependent apoptotic mechanism. Conclusions The recovery of miR-132 resulted in caspase-dependent apoptotic death in glioma cells. MiR-132 that was newly discovered represents a newly targeting mechanism in treatment for glioma. |
| doi_str_mv | 10.1016/j.biopha.2016.01.022 |
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SIRT1 might promote tumorigenesis in human glioma. Methods Here, we investigated whether miR-132 regulate the expression of SIRT1 and its downstream SREBP (Sterol regulatory element-binding protein)-lipogenesis-cholesterogenesis metabolic pathway in human glioma cells. Furthermore, we studied the effect on biology function of glioma cell induced by miR-132. Results MiR-132 inhibited SIRT1 and SREBP-1c expression and downregulated their targeted genes, including HMGCR and FASN. MiR-132 suppressed the cell growth, tumorigenicity, the invasion of glioma cells and migration as well as promoted their apoptosis. The pathways associated with cancer progression and tumorigenicity, and induce glioma cell apoptosis has been inhibited by miR-132 involving in a caspase-dependent apoptotic mechanism. Conclusions The recovery of miR-132 resulted in caspase-dependent apoptotic death in glioma cells. MiR-132 that was newly discovered represents a newly targeting mechanism in treatment for glioma.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2016.01.022</identifier><identifier>PMID: 26898440</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Apoptosis ; Apoptosis - genetics ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Cell Line, Tumor ; Cell Movement - genetics ; Cell Proliferation ; Cholesterol - metabolism ; Down-Regulation - genetics ; Fatty Acid Synthase, Type I - genetics ; Fatty Acid Synthase, Type I - metabolism ; Fatty Acids - metabolism ; Gene Expression Regulation, Neoplastic ; Glioma ; Glioma - genetics ; Glioma - pathology ; Humans ; Hydroxymethylglutaryl CoA Reductases - genetics ; Hydroxymethylglutaryl CoA Reductases - metabolism ; Internal Medicine ; Lipid metabolism ; Medical Education ; Metabolic Networks and Pathways - genetics ; microRNA ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Neoplasm Invasiveness ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; SIRT1 ; Sirtuin 1 - genetics ; Sirtuin 1 - metabolism ; SREBP-1c ; Sterol Regulatory Element Binding Protein 1 - genetics ; Sterol Regulatory Element Binding Protein 1 - metabolism</subject><ispartof>Biomedicine & pharmacotherapy, 2016-03, Vol.78, p.177-184</ispartof><rights>Elsevier Masson SAS</rights><rights>2016 Elsevier Masson SAS</rights><rights>Copyright © 2016 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-45ff970de7f451c2eaf485de47e0bda9f9a312844738a35867fc45c10e1620523</citedby><cites>FETCH-LOGICAL-c417t-45ff970de7f451c2eaf485de47e0bda9f9a312844738a35867fc45c10e1620523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2016.01.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26898440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yunjun</creatorcontrib><creatorcontrib>Zhang, Jinqian</creatorcontrib><creatorcontrib>He, Jingliang</creatorcontrib><creatorcontrib>Zhou, Wenjie</creatorcontrib><creatorcontrib>Xiang, Guoan</creatorcontrib><creatorcontrib>Xu, Ruxiang</creatorcontrib><title>MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Abstract Background The inhibition role of miRNA (microRNA or miR) on cancer signaling pathways has been used to prospective cancer treatment. SIRT1 might promote tumorigenesis in human glioma. Methods Here, we investigated whether miR-132 regulate the expression of SIRT1 and its downstream SREBP (Sterol regulatory element-binding protein)-lipogenesis-cholesterogenesis metabolic pathway in human glioma cells. Furthermore, we studied the effect on biology function of glioma cell induced by miR-132. Results MiR-132 inhibited SIRT1 and SREBP-1c expression and downregulated their targeted genes, including HMGCR and FASN. MiR-132 suppressed the cell growth, tumorigenicity, the invasion of glioma cells and migration as well as promoted their apoptosis. The pathways associated with cancer progression and tumorigenicity, and induce glioma cell apoptosis has been inhibited by miR-132 involving in a caspase-dependent apoptotic mechanism. Conclusions The recovery of miR-132 resulted in caspase-dependent apoptotic death in glioma cells. MiR-132 that was newly discovered represents a newly targeting mechanism in treatment for glioma.</description><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation</subject><subject>Cholesterol - metabolism</subject><subject>Down-Regulation - genetics</subject><subject>Fatty Acid Synthase, Type I - genetics</subject><subject>Fatty Acid Synthase, Type I - metabolism</subject><subject>Fatty Acids - metabolism</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Glioma</subject><subject>Glioma - genetics</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl CoA Reductases - genetics</subject><subject>Hydroxymethylglutaryl CoA Reductases - metabolism</subject><subject>Internal Medicine</subject><subject>Lipid metabolism</subject><subject>Medical Education</subject><subject>Metabolic Networks and Pathways - genetics</subject><subject>microRNA</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Neoplasm Invasiveness</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>SIRT1</subject><subject>Sirtuin 1 - genetics</subject><subject>Sirtuin 1 - metabolism</subject><subject>SREBP-1c</subject><subject>Sterol Regulatory Element Binding Protein 1 - genetics</subject><subject>Sterol Regulatory Element Binding Protein 1 - metabolism</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokPhDRDykk2Cf-Nkg1SqApXKj2bK2nKcm8bTZJzaDmjeHkdTWLBhZVn67r0630HoNSUlJbR6ty9b5-fBlCz_SkJLwtgTtKGNJEVFiHqKNkRJXnDO2Bl6EeOeECIrXj9HZ6yqm1oIskHzF2eD3369KChn2JolAjazn5OPLmLf47vR-clgC-MYcRqCX-4G3I7e3psOViANgHfbqw_fC2rxBMm0fnQWzyYNv8wRBxhNgg4nj3fX21v6Ej3rzRjh1eN7jn58vLq9_FzcfPt0fXlxU1hBVSqE7PtGkQ5ULyS1DEwvatmBUEDazjR9YzhlOYPiteGyrlRvhbSUAK0YkYyfo7envXPwDwvEpCcX1xTmAH6JmqpKVUzWtcioOKHZRIwBej0HN5lw1JTo1bXe65NrvbrWhOrsOo-9ebywtBN0f4f-yM3A-xMAOedPB0FH6-BgoXMBbNKdd_-78O8CO7qDs2a8hyPEvV_CITvUVEemid6tfa91U8lz1ZTx30sYpME</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Li, Yunjun</creator><creator>Zhang, Jinqian</creator><creator>He, Jingliang</creator><creator>Zhou, Wenjie</creator><creator>Xiang, Guoan</creator><creator>Xu, Ruxiang</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1</title><author>Li, Yunjun ; Zhang, Jinqian ; He, Jingliang ; Zhou, Wenjie ; Xiang, Guoan ; Xu, Ruxiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-45ff970de7f451c2eaf485de47e0bda9f9a312844738a35867fc45c10e1620523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation</topic><topic>Cholesterol - metabolism</topic><topic>Down-Regulation - genetics</topic><topic>Fatty Acid Synthase, Type I - genetics</topic><topic>Fatty Acid Synthase, Type I - metabolism</topic><topic>Fatty Acids - metabolism</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Glioma</topic><topic>Glioma - genetics</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl CoA Reductases - genetics</topic><topic>Hydroxymethylglutaryl CoA Reductases - metabolism</topic><topic>Internal Medicine</topic><topic>Lipid metabolism</topic><topic>Medical Education</topic><topic>Metabolic Networks and Pathways - genetics</topic><topic>microRNA</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Neoplasm Invasiveness</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>SIRT1</topic><topic>Sirtuin 1 - genetics</topic><topic>Sirtuin 1 - metabolism</topic><topic>SREBP-1c</topic><topic>Sterol Regulatory Element Binding Protein 1 - genetics</topic><topic>Sterol Regulatory Element Binding Protein 1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yunjun</creatorcontrib><creatorcontrib>Zhang, Jinqian</creatorcontrib><creatorcontrib>He, Jingliang</creatorcontrib><creatorcontrib>Zhou, Wenjie</creatorcontrib><creatorcontrib>Xiang, Guoan</creatorcontrib><creatorcontrib>Xu, Ruxiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yunjun</au><au>Zhang, Jinqian</au><au>He, Jingliang</au><au>Zhou, Wenjie</au><au>Xiang, Guoan</au><au>Xu, Ruxiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>78</volume><spage>177</spage><epage>184</epage><pages>177-184</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Abstract Background The inhibition role of miRNA (microRNA or miR) on cancer signaling pathways has been used to prospective cancer treatment. SIRT1 might promote tumorigenesis in human glioma. Methods Here, we investigated whether miR-132 regulate the expression of SIRT1 and its downstream SREBP (Sterol regulatory element-binding protein)-lipogenesis-cholesterogenesis metabolic pathway in human glioma cells. Furthermore, we studied the effect on biology function of glioma cell induced by miR-132. Results MiR-132 inhibited SIRT1 and SREBP-1c expression and downregulated their targeted genes, including HMGCR and FASN. MiR-132 suppressed the cell growth, tumorigenicity, the invasion of glioma cells and migration as well as promoted their apoptosis. The pathways associated with cancer progression and tumorigenicity, and induce glioma cell apoptosis has been inhibited by miR-132 involving in a caspase-dependent apoptotic mechanism. Conclusions The recovery of miR-132 resulted in caspase-dependent apoptotic death in glioma cells. MiR-132 that was newly discovered represents a newly targeting mechanism in treatment for glioma.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>26898440</pmid><doi>10.1016/j.biopha.2016.01.022</doi><tpages>8</tpages></addata></record> |
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| subjects | Apoptosis Apoptosis - genetics Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation Cholesterol - metabolism Down-Regulation - genetics Fatty Acid Synthase, Type I - genetics Fatty Acid Synthase, Type I - metabolism Fatty Acids - metabolism Gene Expression Regulation, Neoplastic Glioma Glioma - genetics Glioma - pathology Humans Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Internal Medicine Lipid metabolism Medical Education Metabolic Networks and Pathways - genetics microRNA MicroRNAs - genetics MicroRNAs - metabolism Neoplasm Invasiveness RNA, Messenger - genetics RNA, Messenger - metabolism SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism SREBP-1c Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism |
| title | MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1 |
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